@article{oai:niigata-u.repo.nii.ac.jp:00021134, author = {佐藤, 攻}, issue = {2}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Feb}, note = {In order to clarify the influence of obstructive cholangitis on the hepatic functional reserve in 31 patients with obstructive jaundice, the concentration of bile acid in the stagnant bile was measured using high performance liquid chromatography. Hepatic functional reserve was evaluated quantitatively by serum bilirubin decreasing rate after biliary drainage (b value). The following results were obtained : 1) b value was significantly (P<0.05) worse in 17 patients with obstructive cholangitis than that in 14 patients without cholangitis. 2) In patients with cholangitis, total bile acid concentration (TBA) and the ratio of cholic acid to chenodeoxycholic acid (C/CDC) in the stagnant bile were significantly (P<0.05) lower than those in patients without cholangitis. 3) A significant positive correlation (r=0.519, P<0.02) was observed between TBA in the stagnant bile and b value. These results suggest that biliary infection deteriorates bile acid metabolism further in obstructive jaundice, and that impaired bile acid metabolism and the damage of hepatic functional reserve seem to correlate closely to each other.}, pages = {67--75}, title = {閉塞性黄疸における欝滞胆汁の胆汁酸分析 : 特に閉塞性胆管炎との関連について}, volume = {106}, year = {1992} }