@article{oai:niigata-u.repo.nii.ac.jp:00021096,
 author = {小山, 覚},
 issue = {3},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Mar},
 note = {The inhibitory effect of human interferon-alpha and interferon-gamma on the colony formation of CFU-GM was studied using peripheral blood and bone marrow cells in patients with chronic myelogenous leukemia (CML) and healthy donors. Both types of interferon inhibited colony growth of CFU-GM in CML and health donors. Interferon-alpha suppressed CFU-GM in some patients with CML more strongly than that in healthy donors. Whereas interferon-gamma suppressed CFU-GM in healthy donors more strongly than that in patients with CML. The CFU-GM in peripheral blood mononuclear cells with CML had significantly lower sensitivity to interferon-gamma than that in bone marrow mononuclear cells with CML. These findings indicate that the inhibitory effect of interferon, at least in part, is mediated by hematopoietic accessory cells in blood and bone marrow. From this study, it was suggested that interferon-alpha is a more active therapeutic agent than interferon-gamma for patients with CML. There were some co-relationship between the clinical effect of interferon-alpha and the sensitivity of CFU-GM in patients with CML. In conclusion, the sensitivity test of CFU-GM is beneficial to screening of therapeutic agents in CML.},
 pages = {213--220},
 title = {慢性骨髄性白血病(CML)に対する薬物療法の可能性 : 血液幹細胞培養法を応用した薬剤感受性試験と臨床(α型とγ型インターフェロン)},
 volume = {106},
 year = {1992}
}