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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第106巻第4号

脳虚血後生存率に及ぼす脳損傷, 麻酔薬の影響に関する研究

http://hdl.handle.net/10191/39653
http://hdl.handle.net/10191/39653
db238b9f-4284-4296-9b8d-0c64f1c0bac8
名前 / ファイル ライセンス アクション
106(04)_322-332.pdf 106(04)_322-332.pdf (2.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-15
タイトル
タイトル 脳虚血後生存率に及ぼす脳損傷, 麻酔薬の影響に関する研究
タイトル
言語 en
タイトル 脳虚血後生存率に及ぼす脳損傷, 麻酔薬の影響に関する研究
言語
言語 jpn
キーワード
主題Scheme Other
主題 brain injury
キーワード
主題Scheme Other
主題 brain ischemia
キーワード
主題Scheme Other
主題 antiischemic factors
キーワード
主題Scheme Other
主題 anesthetics
キーワード
主題Scheme Other
主題 survival rate
キーワード
主題Scheme Other
主題 脳損傷
キーワード
主題Scheme Other
主題 脳虚血
キーワード
主題Scheme Other
主題 抗虚血因子
キーワード
主題Scheme Other
主題 麻酔薬
キーワード
主題Scheme Other
主題 生存率
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Effects of Brain Injury and Anesthertics on Survival Rate Following Brain Ischemia in Mice
著者 高畑, 与四夫

× 高畑, 与四夫

WEKO 129196

高畑, 与四夫

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著者別名
識別子 129197
識別子Scheme WEKO
姓名 Takahata, Yoshio
抄録
内容記述タイプ Abstract
内容記述 Although brain resuscitation measures for the ischemic-anoxic brain injury have been reported inrecent years, none of these is promising in clinical practice. Intrinsic protective mechanisms can be provided in artifically injured brain. The administration of exogenous nerve growth facter (NGF) inhibits naturally occurring cholinergic neuronal death and promote neuronal survival in the sympathetic ganglia after axotomy. Thus, we examined the protective effect of brain injury and anesthetics, on brain ischemia induced by common carotid artery clipping in mice. Mice were randamly dvided in to 3 groups, the anesthesia group, sham operated group (received surgical incision on the scalp without brain injury) and brain injury group. The brain injury was induced by vertically inserting a 25 gauge hypodermic needle 5mm in depth from the skull into the brain at 4 sites. One week after the brain injury, incomplate brain ischemia was applied for 60 min under pentobarbital (80mg/kg) anesthesia or for 30 min under ketamine (200mg/kg) anesthesia. The survival rate was calculated following brain ischemia in each group up to the 7th postischemic day. The survival rate in the brain injury group in which brain ischemia was produced under pentobarbital anesthesia was significantly higher than in the other groups. Improvement of survival rate in mice with brain injury, however, became insignificant when brain ischemia was imposed during ketamine anesthesia. The results suggest that antiischemic factors are released by the injured brain or that certain unknown protective mechanisms against ischemia become active following brain injury during barbiturarate anesthesia. By contrast, an opposing mechanism might develop under ketamine anesthesia, in which protective effects of brain injury against brain ischemia are masked.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 106, 号 4, p. 322-332, 発行日 1992-04
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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