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脳虚血後生存率に及ぼす脳損傷, 麻酔薬の影響に関する研究
http://hdl.handle.net/10191/39653
http://hdl.handle.net/10191/39653db238b9f-4284-4296-9b8d-0c64f1c0bac8
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-03-15 | |||||
タイトル | ||||||
タイトル | 脳虚血後生存率に及ぼす脳損傷, 麻酔薬の影響に関する研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 脳虚血後生存率に及ぼす脳損傷, 麻酔薬の影響に関する研究 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | brain injury | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | brain ischemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiischemic factors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anesthetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | survival rate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 脳損傷 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 脳虚血 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抗虚血因子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 麻酔薬 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 生存率 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Effects of Brain Injury and Anesthertics on Survival Rate Following Brain Ischemia in Mice | |||||
著者 |
高畑, 与四夫
× 高畑, 与四夫 |
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著者別名 | ||||||
識別子 | 129197 | |||||
識別子Scheme | WEKO | |||||
姓名 | Takahata, Yoshio | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although brain resuscitation measures for the ischemic-anoxic brain injury have been reported inrecent years, none of these is promising in clinical practice. Intrinsic protective mechanisms can be provided in artifically injured brain. The administration of exogenous nerve growth facter (NGF) inhibits naturally occurring cholinergic neuronal death and promote neuronal survival in the sympathetic ganglia after axotomy. Thus, we examined the protective effect of brain injury and anesthetics, on brain ischemia induced by common carotid artery clipping in mice. Mice were randamly dvided in to 3 groups, the anesthesia group, sham operated group (received surgical incision on the scalp without brain injury) and brain injury group. The brain injury was induced by vertically inserting a 25 gauge hypodermic needle 5mm in depth from the skull into the brain at 4 sites. One week after the brain injury, incomplate brain ischemia was applied for 60 min under pentobarbital (80mg/kg) anesthesia or for 30 min under ketamine (200mg/kg) anesthesia. The survival rate was calculated following brain ischemia in each group up to the 7th postischemic day. The survival rate in the brain injury group in which brain ischemia was produced under pentobarbital anesthesia was significantly higher than in the other groups. Improvement of survival rate in mice with brain injury, however, became insignificant when brain ischemia was imposed during ketamine anesthesia. The results suggest that antiischemic factors are released by the injured brain or that certain unknown protective mechanisms against ischemia become active following brain injury during barbiturarate anesthesia. By contrast, an opposing mechanism might develop under ketamine anesthesia, in which protective effects of brain injury against brain ischemia are masked. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 4, p. 322-332, 発行日 1992-04 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |