@article{oai:niigata-u.repo.nii.ac.jp:00020968,
 author = {鴨井, 久司 and 中村, 浩淑 and 島津, 章},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {We report the results of follow up for 7 to 8 years in two cases reported with syndrome of inappropriate secretion of TSH (SITSH). One case was due to TSH producing pituitary tumor and another one generalized resistance to thyroid hormone. In the former patient, at follow-up for 6 years after improvement by transshenoidal adenomectomy and then with methimazol treatment, he had recurrent thyrotoxicosis due to excessive secretion of serum TSH and α TSH with regrowth of pituitary tumor shown by MRI. Subcutaneous injection with 100μg of octreotide decreased the levels of TSH and α TSH and produced strong nausea and vomiting. The subcutaneous injection with continuous and intermittent time (12.5μg/2 hours) by infusion pump, however, improved the serum levels and regrowth of the tumor, and then thyrotoxicosis without the side effects. At 10 months after the therapy, recurrent thyrotoxicosis ocurred and was improved by additional administration of methimazol. The latter patient has normal growth for 7 years. Characteristics of thyroid recptor in the fibroblast were similar to normal by immunostaining or Western blot method, and length of the erb A β receptor gene was normal. The observation indicates that we need to follow up patient with SITSH for a long period.},
 pages = {359--370},
 title = {2) TSH不適切分泌症候群の2例(シンポジウム 甲状腺疾患の臨床, 第469回新潟医学会)},
 volume = {106},
 year = {1992}
}