@article{oai:niigata-u.repo.nii.ac.jp:00020937,
 author = {真柄, 純子},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {An experiment was carried out to examine mutagenicity and co-mutagenicity of bile. Bile was obtained from the gallbladders resected from patients with various diseases. The bile samples were provided from several hospitals in Niigata Prefecture from September, 1987 to January, 1989. Of 113 samples tested by using Kada's spore rec assay method, 14 (12.4%) showed positive results. The samples of mutagenic bile were from 3 cases of gallbladder cancer, 3 cholelithiasis, 2 gastric cancer with cholelithiasis, 1 polyp of the gallbladder, 1 gallbladder and lung cancers, 1 cervical cancer of the uterus, 1 liver cancer, 1 rectal cancer and 1 rectal cancer with cholelithiasis. Bile of the malignant disease was found to be more mutagenic than those of the benign ones. Bile of gallbladder cancer was more mutagenic than other benign diseases of the gallbladder. In addition to the examination of mutagenicity, it was tested whether or not the bile enhanced the mutagenic activity of a known mutagen, Mitomycin C (co-mutagenicity test). Of 30 samples tested, 22 (73.3 %) showed positive results.},
 pages = {543--554},
 title = {“Rec assay”を用いたヒト胆汁の変異原性について},
 volume = {106},
 year = {1992}
}