@article{oai:niigata-u.repo.nii.ac.jp:00020936,
 author = {森, 宏},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {To investigate the influence of the intensive treatment for malignant brain tumors on the cellular immunological functions, the dynamic changes of the peripheral blood lymphocytes subsets during the therapy was studied. PBLs collected from 21 maligmant brain tumor patients were examined by two-color flow cytometric analysis using Leu series monoclonal antibodies. Patients were divided into three groups according to the treatment regimen; (R) brain irradiation only, n=4; (A) (R)＋1-(4-amino-2-methyl-5-pyrimidyl) methyl-3-nitrosourea hydrochloride, n=7; and (I) (A)+OK 432 or interferon-β, n=10. Results presented herein are summarized as below; 1) T(Leu 4+12-) cells have increased in all groups and B (Leu 4-12+) cells have decreased significantly (p＜0.05) in groups R and A. B cells have also decreased in group I. 2) All groups showed an increase in activated T (Leu 4+HLADR+) cells before the treatment. Moreover, in groups R and A, these activated T cells have increased significantly (p＜0.05) during the therapy. Activated T cells have also increased in group I. 3) CD4/CD8 ratios have decreased in groups R and A. In group I, however, it has remained nearly constant during the therapy. 4) Cytotoxic T (Leu2a+15-) cells have increased almost in parallel with activated T cells. So, the major component of the increased aetivated Tcells were thought to be the cytotoxic Tcells. 5) Strong NK(Leu 7-11+) cells have increased in all groups and moderate NK (Leu7+11+) cells have increased in groups R and A. Our data may suggest that the immunological states of the patients, especially those treated with biological response modifiers, get to be favorable state from the view point of the antitumor immunity during the intensive treatment.},
 pages = {536--542},
 title = {悪性脳腫瘍患者末梢血リンパ球サブセット動態におよぼす集学的治療の効果},
 volume = {106},
 year = {1992}
}