@article{oai:niigata-u.repo.nii.ac.jp:00020935,
 author = {伏島, 徹},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {The growth rate, local cerebral blood flow (LCBF), local cerebral glucose utilization (LCGU), local cerebral protein synthesis (LCPS) or DNA synthesis of brain tumors were studied in experimental rat brain tumors before and after irradiation, using quantitative autoradiography and immunohistochemical techniques. Two strains of rat brain tumor induced by Rous sarcoma virus were used. Strain A was biologically more malignant and less sensitive to radiation than strain B. The LCGU, LCPS and DNA synthesis reduced after irradiation but the LCBF changed little in both A and B tumors. The value of LCGU in the tumor decreased slowly after irradiation. The reduction rate was greater in strain B tumor than in strain A tumor. The value of LCPS decreased rapidly after irradiation in both tumors. The reduction rate was greater in strain B tumor than in strain A tumor. The labeling index of S-phase cells (LI) decreased rapidly, as much as that of LCPS, after irradiation in both tumors and the reduction rate of LI was also greater in strain B tumor than in strain A tumor. These findings indicate that the reduction of LCPS, DNA synthesis and LCGU may represent the radiosensitivity of these tumors. The reduction of LCPS and LI occured earlier than those of LCGU and tumor size. The radiosensitivity of tumors could be predicted by measuring the changes in LI and LCPS before recognition of the reduction in tumor size.},
 pages = {528--535},
 title = {実験脳腫瘍の増殖能及び局所循環・代謝におよぼす放射線照射の影響},
 volume = {106},
 year = {1992}
}