@article{oai:niigata-u.repo.nii.ac.jp:00020933,
 author = {尤, 春来 and 仲澤, 幹雄},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {Using the isolated rat aortas with or without endothelium, the effects of Taraxacum-extract on the vascular smooth muscle were studied. The contraction was induced by phenylephreine. In the preparations without endothelium Taraxacum-extract produced a dose-dependent increase in tension, while in preparations with intact endothelium high doses (0.1 and 0.3ml) of this extract produced relaxation. Taraxacum contained 265mM K^+ and 53mM Na^+. However, the solution containing 265mM K^+ and 53mM Na^+ induced only a contraction at a higher dose (0.03ml). The contraction was greater in the aorta without entodthlium than in the aorta with endothelium. Indomethacin(10^<-5> .M) had no effect on the Taraxacum-extract-induced relaxation, while the contraction induced with lower concentrations of Taraxacum-extract was potentiated. These results indicate that Taraxacum-extract produces endothelium-dependent relaxation (due probably to EDRF) at higher doses. The release of vasorelaxant prostaglandin(s) was indicated. The contraction induced with Taraxacum-extract was not due to K^+ and Na^+ ion contained in it.},
 pages = {513--517},
 title = {ラット摘出大動脈平滑筋に対する蒲公英の作用},
 volume = {106},
 year = {1992}
}