{"created":"2021-03-01T06:25:51.978050+00:00","id":20872,"links":{},"metadata":{"_buckets":{"deposit":"f59f092c-ad28-4a70-b8fd-e6a03879f582"},"_deposit":{"id":"20872","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20872"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00020872","sets":["453:456","471:537:538:1172"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of Methylene Blue on the Relaxation and Increases in Cyclic GMP Concentrations of Vascular Smooth Muscle Produced by NO-forming Vasodilators and Atriopeptin"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"641","bibliographicPageStart":"631","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the isolated endothelium-removed rabbit aorta (RA) precontracted with phenylephrine, 15 min treatment with methylene blue (15 min-MB) resulted in a rightward shift of the dose-response curve (DRC) for nitroglycerin (NTG) and nitric oxide (NO), while DRC for NaNO_2, sodium nitroprusside (SNP) and atriopeptin (ANP) was not affected. DRC for SNP was not affected in the dog coronary artery (DCA) (endothelium-removed and precontracted with KCl), while DRC for SNP was shifted to the right in the rat and guinea pig aorta. The relaxation by SNP or NaNO_2 was attenuated after 60 min-MB in RA but not in DCA. The relaxation by ANP was not affected after 60-min MB. While increases in tissue cyclic GMP in RA by NTG and NO were attenuated after 15 min-MB, the increases by SNP, NaNO_2 and ANP were not affected even after 60 min-MB. The relaxant effects of 8-Br cyclic GMP were not attenuated after 60 min-MB. Thus, the inhibition by MB of relaxation by SNP and NaNO_2 was due to its action on a process or processes operative before and/or in parallel with the accumulation of cyclic GMP. Species differences in the penetrability of MB were suggested.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"128390","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sasage, Hiroki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"捧, 博輝"}],"nameIdentifiers":[{"nameIdentifier":"128389","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"106(07)_631-641.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"106(07)_631-641.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/20872/files/106(07)_631-641.pdf"},"version_id":"3af80666-a8c7-420d-9a2b-e0bff45aaf2d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vascular smooth muscle","subitem_subject_scheme":"Other"},{"subitem_subject":"NO-forming vasodilators","subitem_subject_scheme":"Other"},{"subitem_subject":"atriopeptin","subitem_subject_scheme":"Other"},{"subitem_subject":"methylene blue","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclic GMP","subitem_subject_scheme":"Other"},{"subitem_subject":"血管平滑筋","subitem_subject_scheme":"Other"},{"subitem_subject":"心房性ナトリウム利尿ホルモン","subitem_subject_scheme":"Other"},{"subitem_subject":"メチレンブルー","subitem_subject_scheme":"Other"},{"subitem_subject":"サイクリックGMP","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について"},{"subitem_title":"NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1172"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-17"},"publish_date":"2016-03-17","publish_status":"0","recid":"20872","relation_version_is_last":true,"title":["NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:33.492629+00:00"}