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NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について
http://hdl.handle.net/10191/39838
http://hdl.handle.net/10191/398381de3e37b-2e01-47ea-a489-c336b4fc49c3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
106(07)_631-641.pdf (1.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-03-17 | |||||
| タイトル | ||||||
| タイトル | NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について | |||||
| タイトル | ||||||
| タイトル | NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | vascular smooth muscle | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NO-forming vasodilators | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | atriopeptin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | methylene blue | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cyclic GMP | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 血管平滑筋 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 心房性ナトリウム利尿ホルモン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | メチレンブルー | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | サイクリックGMP | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Effects of Methylene Blue on the Relaxation and Increases in Cyclic GMP Concentrations of Vascular Smooth Muscle Produced by NO-forming Vasodilators and Atriopeptin | |||||
| 著者 |
捧, 博輝
× 捧, 博輝 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 128390 | |||||
| 姓名 | Sasage, Hiroki | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the isolated endothelium-removed rabbit aorta (RA) precontracted with phenylephrine, 15 min treatment with methylene blue (15 min-MB) resulted in a rightward shift of the dose-response curve (DRC) for nitroglycerin (NTG) and nitric oxide (NO), while DRC for NaNO_2, sodium nitroprusside (SNP) and atriopeptin (ANP) was not affected. DRC for SNP was not affected in the dog coronary artery (DCA) (endothelium-removed and precontracted with KCl), while DRC for SNP was shifted to the right in the rat and guinea pig aorta. The relaxation by SNP or NaNO_2 was attenuated after 60 min-MB in RA but not in DCA. The relaxation by ANP was not affected after 60-min MB. While increases in tissue cyclic GMP in RA by NTG and NO were attenuated after 15 min-MB, the increases by SNP, NaNO_2 and ANP were not affected even after 60 min-MB. The relaxant effects of 8-Br cyclic GMP were not attenuated after 60 min-MB. Thus, the inhibition by MB of relaxation by SNP and NaNO_2 was due to its action on a process or processes operative before and/or in parallel with the accumulation of cyclic GMP. Species differences in the penetrability of MB were suggested. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 7, p. 631-641, 発行日 1992-07 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
