{"_buckets": {"deposit": "f59f092c-ad28-4a70-b8fd-e6a03879f582"}, "_deposit": {"id": "20872", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20872"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00020872", "sets": ["456", "1172"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Effects of Methylene Blue on the Relaxation and Increases in Cyclic GMP Concentrations of Vascular Smooth Muscle Produced by NO-forming Vasodilators and Atriopeptin"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "641", "bibliographicPageStart": "631", "bibliographicVolumeNumber": "106", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In the isolated endothelium-removed rabbit aorta (RA) precontracted with phenylephrine, 15 min treatment with methylene blue (15 min-MB) resulted in a rightward shift of the dose-response curve (DRC) for nitroglycerin (NTG) and nitric oxide (NO), while DRC for NaNO_2, sodium nitroprusside (SNP) and atriopeptin (ANP) was not affected. DRC for SNP was not affected in the dog coronary artery (DCA) (endothelium-removed and precontracted with KCl), while DRC for SNP was shifted to the right in the rat and guinea pig aorta. The relaxation by SNP or NaNO_2 was attenuated after 60 min-MB in RA but not in DCA. The relaxation by ANP was not affected after 60-min MB. While increases in tissue cyclic GMP in RA by NTG and NO were attenuated after 15 min-MB, the increases by SNP, NaNO_2 and ANP were not affected even after 60 min-MB. The relaxant effects of 8-Br cyclic GMP were not attenuated after 60 min-MB. Thus, the inhibition by MB of relaxation by SNP and NaNO_2 was due to its action on a process or processes operative before and/or in parallel with the accumulation of cyclic GMP. Species differences in the penetrability of MB were suggested.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "128390", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sasage, Hiroki"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "捧, 博輝"}], "nameIdentifiers": [{"nameIdentifier": "128389", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "106(07)_631-641.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "106(07)_631-641.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/20872/files/106(07)_631-641.pdf"}, "version_id": "3af80666-a8c7-420d-9a2b-e0bff45aaf2d"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "vascular smooth muscle", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NO-forming vasodilators", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atriopeptin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "methylene blue", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cyclic GMP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "血管平滑筋", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心房性ナトリウム利尿ホルモン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "メチレンブルー", "subitem_subject_scheme": "Other"}, {"subitem_subject": "サイクリックGMP", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について"}, {"subitem_title": "NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1172"], "permalink_uri": "http://hdl.handle.net/10191/39838", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-03-17"}, "publish_date": "2016-03-17", "publish_status": "0", "recid": "20872", "relation": {}, "relation_version_is_last": true, "title": ["NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について"], "weko_shared_id": null}