{"_buckets": {"deposit": "f59f092c-ad28-4a70-b8fd-e6a03879f582"}, "_deposit": {"id": "20872", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20872"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00020872"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Effects of Methylene Blue on the Relaxation and Increases in Cyclic GMP Concentrations of Vascular Smooth Muscle Produced by NO-forming Vasodilators and Atriopeptin"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "641", "bibliographicPageStart": "631", "bibliographicVolumeNumber": "106", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "In the isolated endothelium-removed rabbit aorta (RA) precontracted with phenylephrine, 15 min treatment with methylene blue (15 min-MB) resulted in a rightward shift of the dose-response curve (DRC) for nitroglycerin (NTG) and nitric oxide (NO), while DRC for NaNO_2, sodium nitroprusside (SNP) and atriopeptin (ANP) was not affected. DRC for SNP was not affected in the dog coronary artery (DCA) (endothelium-removed and precontracted with KCl), while DRC for SNP was shifted to the right in the rat and guinea pig aorta. The relaxation by SNP or NaNO_2 was attenuated after 60 min-MB in RA but not in DCA. The relaxation by ANP was not affected after 60-min MB. While increases in tissue cyclic GMP in RA by NTG and NO were attenuated after 15 min-MB, the increases by SNP, NaNO_2 and ANP were not affected even after 60 min-MB. The relaxant effects of 8-Br cyclic GMP were not attenuated after 60 min-MB. Thus, the inhibition by MB of relaxation by SNP and NaNO_2 was due to its action on a process or processes operative before and/or in parallel with the accumulation of cyclic GMP. Species differences in the penetrability of MB were suggested.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "128390", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sasage, Hiroki"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6367, \u535a\u8f1d"}], "nameIdentifiers": [{"nameIdentifier": "128389", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "106(07)_631-641.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "106(07)_631-641.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/20872/files/106(07)_631-641.pdf"}, "version_id": "3af80666-a8c7-420d-9a2b-e0bff45aaf2d"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "vascular smooth muscle", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NO-forming vasodilators", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atriopeptin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "methylene blue", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cyclic GMP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8840\u7ba1\u5e73\u6ed1\u7b4b", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5fc3\u623f\u6027\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30db\u30eb\u30e2\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30e1\u30c1\u30ec\u30f3\u30d6\u30eb\u30fc", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30b5\u30a4\u30af\u30ea\u30c3\u30afGMP", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "NO-forming vasodilators\u3068atriopeptin\u306b\u3088\u308b\u8840\u7ba1\u5e73\u6ed1\u7b4b\u306e\u5f1b\u7de9\u3068cyclic GMP\u5897\u52a0\u306b\u5bfe\u3059\u308bmethylene blue\u306e\u52b9\u679c\u306b\u3064\u3044\u3066", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "NO-forming vasodilators\u3068atriopeptin\u306b\u3088\u308b\u8840\u7ba1\u5e73\u6ed1\u7b4b\u306e\u5f1b\u7de9\u3068cyclic GMP\u5897\u52a0\u306b\u5bfe\u3059\u308bmethylene blue\u306e\u52b9\u679c\u306b\u3064\u3044\u3066"}, {"subitem_title": "NO-forming vasodilators\u3068atriopeptin\u306b\u3088\u308b\u8840\u7ba1\u5e73\u6ed1\u7b4b\u306e\u5f1b\u7de9\u3068cyclic GMP\u5897\u52a0\u306b\u5bfe\u3059\u308bmethylene blue\u306e\u52b9\u679c\u306b\u3064\u3044\u3066", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1172"], "permalink_uri": "http://hdl.handle.net/10191/39838", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-17"}, "publish_date": "2016-03-17", "publish_status": "0", "recid": "20872", "relation": {}, "relation_version_is_last": true, "title": ["NO-forming vasodilators\u3068atriopeptin\u306b\u3088\u308b\u8840\u7ba1\u5e73\u6ed1\u7b4b\u306e\u5f1b\u7de9\u3068cyclic GMP\u5897\u52a0\u306b\u5bfe\u3059\u308bmethylene blue\u306e\u52b9\u679c\u306b\u3064\u3044\u3066"], "weko_shared_id": null}