{"created":"2021-03-01T06:25:29.297391+00:00","id":20527,"links":{},"metadata":{"_buckets":{"deposit":"ca010b88-b934-4f11-8d2a-749839aed0da"},"_deposit":{"id":"20527","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20527"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00020527","sets":["453:456","471:537:538:1167"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Basic Study on Alkaline Phosphatase Produced by Human Osteosarcoma Cells"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1183","bibliographicPageStart":"1174","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The exact significance of alkaline phosphatase (ALP) in osteosarcomas is not fully elucidated still now. This basic study was performed to evaluate the validity of ALP as a tumor marker, using three cultured human osteosarcoma cell lines, NOS-1, NOS-2 and KSU, which were derived from conventional osteoblastic type osteosarcoma. The NOS-1 cell line had always the highest activity of ALP, while the KSU cell line had no detectable activity. Both NOS-1 and NOS-2 cells produced ordinary bone-type ALP, but did not produced any tumor-specific variants. The levels of ALP secreted NOS-1 or NOS-2 cells in media were closely related to the cell number. Moreover, the serum levels in nude mice bearing NOS-1 or NOS-2 cells also were closely related to the tumor weight. These data indicate that ALP is useful as a marker in the serum to monitor therapeutic effect for the patients with ALP-producing osteosarcoma. However, it was proved that an antineoplastic agent, methotrexate, temporarily stimulated osteosarcoma cells to produce ALP. Messenger RNA of bone type ALP was always reflected in the ALP activity in osteosarcoma cells.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"126666","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hotta, Tetuo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"堀田, 哲夫"}],"nameIdentifiers":[{"nameIdentifier":"126665","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"106(12)_1174-1183.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"106(12)_1174-1183.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/20527/files/106(12)_1174-1183.pdf"},"version_id":"63f42f4a-656f-4f29-8dab-fffc410ab722"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"alkaline phosphatase","subitem_subject_scheme":"Other"},{"subitem_subject":"osteosarcoma","subitem_subject_scheme":"Other"},{"subitem_subject":"cell culture","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor marker","subitem_subject_scheme":"Other"},{"subitem_subject":"アルカリフォスファターゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"骨肉腫","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞培養","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍マーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"骨肉腫におけるアルカリフォスファターゼの意義に関する基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨肉腫におけるアルカリフォスファターゼの意義に関する基礎的研究"},{"subitem_title":"骨肉腫におけるアルカリフォスファターゼの意義に関する基礎的研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1167"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-25"},"publish_date":"2016-03-25","publish_status":"0","recid":"20527","relation_version_is_last":true,"title":["骨肉腫におけるアルカリフォスファターゼの意義に関する基礎的研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:15.955855+00:00"}