@article{oai:niigata-u.repo.nii.ac.jp:00020526, author = {日高, 俊彦}, issue = {12}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Dec}, note = {Microvacular architectural changes and proliferation of endothelial cells in the rat brain following local cold injury were studied by the cerebrovascular casting method with scanning electron microscopy and by immunohistochemistry using a monoclonal antibody to bromodeoxyuridine (BrdU). At 7 and 14 days after injury, the newly formed vessels at the border of the lesion demonstraed tortuousness, nodular protrusions and anastomoses which were also seen in the active stage of the vascularization of developing fetal rat brain. At 21 days, these feature could hardly be observed and smoothly running microvessels appeared. At 28 days, the microvascular architecture was completely reconstructed, but there were decreased numbers of capillaries and narrowing of them in the marginal zone. The BrdU labeling index of endothelial cells was elevated from 2 days after injury and reached a peak of 2.0% at 7 days after injury. Labeled endothelial cells disappeared 14 days later. It was suspected that changes in the microvascular architecture were closely related to the proliferation of endothelial cells. It seems that the process of neovascularization after cold injury resembles that in the developing fetal brain.}, pages = {1164--1173}, title = {脳損傷後の微小血管構築と血管内皮細胞増殖能の変化}, volume = {106}, year = {1992} }