{"created":"2021-03-01T06:25:29.168670+00:00","id":20525,"links":{},"metadata":{"_buckets":{"deposit":"9f2015e1-86d1-4bc1-9614-b18408713c2c"},"_deposit":{"id":"20525","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20525"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00020525","sets":["453:456","471:537:538:1167"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Relationship Between Changes in Neuronal Activity and Intracellular free Ca^<2+> Concentration Induced by Hypoxia with Glucose Depletion : Simultaneous Recordings of Synaptic Activity and Intracellular free Ca^<2+> Concentration in Rat Hippocampal Slices"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1163","bibliographicPageStart":"1155","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to study the relationship between intracellular free calcium concentration ([Ca^<2+>]_i) and functional neuronal damage by hypoxia, changes in fluorescence of calciumdependent fluerescence of a Ca^<2+> indicator (fura-2) loaded and synaptic responses (population spike and EPSP) were recorded simultaneously from the CA1 region in rat hippocampal slices superfused with deoxygenated Krebs solution with or without glucose depletion at 36～37℃. When slices were exposed to hypoxia with glucose depletion, synaptic responses disappeared in 2 min. The synaptic responses reappeared transiently in 7～8 min during exposure in a majority of slices. [Ca^<2+>]_i increased in two phases：it increased gradually until the reappearance of the transient synaptic responses, and then it showed a rapid and large increase immediately after the disappearance of the transient synaptic responses. After reoxygenation and glucose resupply, synaptic responses did not recover in the slices (8 of 10 slices) in which [Ca^<2+>]_i increased steeply in the second phase, while the synaptic responses recovered in the slices (2 of 10 slices) in which [Ca^<2+>]_i did not show the second phase increase. When slices were exposed to hypoxia in the presence of glucose, only gradual increase in [Ca^<2+>]_i was observed, and synaptic responses recovered with augmentation after reoxygenation. These results suggest that the rapid and large increases in [Ca^<2+>]_i in the second phase link to acute functional neuronal cell damage by hypoxia with glucose depletion. The results also suggest that the presence of glucose prevents the large increase in [Ca^<2+>]_i.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"126662","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Abe, Takashi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"阿部, 崇"}],"nameIdentifiers":[{"nameIdentifier":"126661","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"106(12)_1155-1163.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"106(12)_1155-1163.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/20525/files/106(12)_1155-1163.pdf"},"version_id":"6e122431-b78d-4812-8020-f5a2a556129b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hippocampal slice","subitem_subject_scheme":"Other"},{"subitem_subject":"Synaptic responses","subitem_subject_scheme":"Other"},{"subitem_subject":"Intracellular free calcium","subitem_subject_scheme":"Other"},{"subitem_subject":"Simultaneous recording","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypoxia","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucose depletion","subitem_subject_scheme":"Other"},{"subitem_subject":"海馬切片","subitem_subject_scheme":"Other"},{"subitem_subject":"シナプス活動","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内遊離カルシウム","subitem_subject_scheme":"Other"},{"subitem_subject":"同時記録","subitem_subject_scheme":"Other"},{"subitem_subject":"低酸素","subitem_subject_scheme":"Other"},{"subitem_subject":"無グルコース","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"低酸素および低酸素+無グルコースによる細胞内遊離カルシウム濃度変化と海馬神経活動障害 : ラット海馬切片におけるシナプス活動と細胞内遊離カルシウム濃度の同時記録","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低酸素および低酸素+無グルコースによる細胞内遊離カルシウム濃度変化と海馬神経活動障害 : ラット海馬切片におけるシナプス活動と細胞内遊離カルシウム濃度の同時記録"},{"subitem_title":"低酸素および低酸素+無グルコースによる細胞内遊離カルシウム濃度変化と海馬神経活動障害 : ラット海馬切片におけるシナプス活動と細胞内遊離カルシウム濃度の同時記録","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1167"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-25"},"publish_date":"2016-03-25","publish_status":"0","recid":"20525","relation_version_is_last":true,"title":["低酸素および低酸素+無グルコースによる細胞内遊離カルシウム濃度変化と海馬神経活動障害 : ラット海馬切片におけるシナプス活動と細胞内遊離カルシウム濃度の同時記録"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:16.012992+00:00"}