@article{oai:niigata-u.repo.nii.ac.jp:00020390,
 author = {渡辺, 達雄},
 issue = {1},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jan},
 note = {Remarkable functional recovery has been observed in the hemispherectomized animals and it is conceivable that the remaining cerebral hemisphere is responsible for this recovery. To disclose biochemical basis of this functinal recovery, rats were hemispherectomized neonatally or at 3 month after birth, and proteins of the remaining cerebral hemisphere were analyzed. At one, two and four weeks after the hemispherectomy, ^<14>C-labelled leucine was injected intracerebrally and rats were decapitated one hour after the injection. The proteins were fractionated into water-, Triton X100- and SDS-soluble fractions and analysed by SDS polyacrylamide gel- and by two dimensional gel-electrophoresis. CBB stained protein-profiles and relative specific activities of the main proteins calculated from densitigrams of radioautography and CBB staining were compared between the hemispherectomized rats and the control rats. The present results revealed that appreciable extent of changes in protein metabolism in the remaining cerebral hemisphere is not necessary for the functional recovery of the hemispherectomized rat.},
 pages = {53--64},
 title = {大脳半球剔除ラット残存半球皮質の蛋白代謝について : 中枢神経系の可塑性に関連して},
 volume = {107},
 year = {1993}
}