@article{oai:niigata-u.repo.nii.ac.jp:00020340,
 author = {鷲山, 和雄},
 issue = {2},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Feb},
 note = {Placental alkaline phosphatase (PLAP) in cases of primary intracranial germinoma was investigated by the immunohistochemistry and the enzyme immunoassay (EIA). On immunohistochemical examination, positive staining for PLAP was observed in neoplastic cells in all of the 15 cases examined, while the positive to negative cell ratio varied from 2 to 90%. No positive staining was observed in 97 primary intracranial nongerm cell neoplasms, but staining was observed in one of the 3 cancer metastasis cases. EIA analysis revealed intracranial PLAP levels in cerebrospinal fluid (CSF) exceeding the detection limit (20 mU/L) in 12 of the 15 germinoma patients. The range of PLAP levels in these patients was 25～1400 mU/L. Approximate, but not absolute correlation was seen between CSF PLAP levels and immunostaining of tissue sections. On the other hand, serum PLAP levels of all but one patients were under the normal cut-off level (60 mU/L). In 70 patients with primary intracranial various diseases except germ cell tumors, PLAP levels in CSF were under the detection limit. From these findings it was shown that PLAP could be used as a very useful marker for clinical and pathological diagnosis and further analysis of primary intracranial germinoma.},
 pages = {157--164},
 title = {頭蓋内胚腫における胎盤性アルカリフォスファターゼの臨床病理学的研究},
 volume = {107},
 year = {1993}
}