@article{oai:niigata-u.repo.nii.ac.jp:00020210,
 author = {笠原, 紳},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {To evaluate prognostic factors in diabetic patients with advanced nephropathy, the degree of urinary protein, mean BP, Hb-Alc, serum Ca・IP, hemoglobin levels and mean age were analysed in 18 diabetic patients with persistent proteinuria. These patients included out-patients of the 1st Department of Internal Medicine, Niigata University Hospital from 1982 to 1988. The patients were divided into two groups: One group (Group A) included 8 patients with under 2mg/dl of serum creatinine levels during treatment and the other group (Group B) included 7 patients whose serum creatinine levels increased over 2mg/dl during treatment. The degree of urinary protein and mean BP were significantly lower in Group A. Mean age was significantly older in Group A. These findings suggest that the degree of urinary protein, mean BP and age may be related to the exacerbation of diabetic nephropathy in patients with serum creatinine levels between 1.2 and 2mg/dl. After determining the plot of 1/Cr in 10 patients with over 2 mg/dl of serum creatinine, these patients were further divided into two groups: rapid progression group (Group C N: 7) and slow progression group (Group D N: 3). The degree of urinary protein and mean BP were significantly lower in group D as compared with that in group C. Hb-Alc in group D was significantly higher than that in group C. The findings led us to consider that the degree of urinary protein and mean BP may play an important role in an increase of serum creatinine levels and that blood suger control is not related to the exacerbation of diabetic nephropathy in patients with over 2mg/dl of serum creatinine levels.},
 pages = {361--366},
 title = {糖尿病性腎症による持続性蛋白尿患者の予後左右因子に対する臨床的解析},
 volume = {107},
 year = {1993}
}