@article{oai:niigata-u.repo.nii.ac.jp:00020209, author = {鈴木, 孝幸}, issue = {4}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Apr}, note = {Flash visual evoked potential (VEP) and pure tone auditory evoked potential (AEP) were analyzed on 13 normal, 9 drug naive schizophrenic and 16 continious medicated schizophrenic subjects. Results 1) Drug naive schizophrenic subjects had reduced amplitude on F7 dominantly for VEP-P200 and FP2 and F7, 8 dominantly for AEP-N100 compared with normal subjects. Which indicated schizophrenic subjects had disturbance related the frontal lobe. These were not affected by medication, symptomes, duration of illness. Reduction of VEP's F7-P200 amplitude in schizophrenic subjects was more lower in schizophrenic subjects with psychiatric family history than without psychiatric family history, then it was regarded as trait dependent. 2) Drug naive schizophrenic subjects had reduced amplitude on right hemisphere post temporal-occipital dominantly for VEP-N140 and diffusely for AEP-middle latency evoked potentials compared with normal subjects. These were regarded as abnormal findings corresponding to modality speciffic. Schizophrenic subjects were concluded to have diffuse functional cerebral disturbance. 3) By investigation of continious medicated schizophrenic subjects it was presumed that continious medication normalized the abnormal findings corresponding to modality specific in drug naive schizophrenic subjects except frontal region. Therefor this showed that medication was limitedly effective. 4) Evoked potentials for schizophrenic subjects with long duration of illness were distinguishable from those for schizophrenic subjects with short duration of illness.}, pages = {350--360}, title = {精神分裂病者の誘発電位未服薬精神分裂病者と慢性服薬分裂病者の検討}, volume = {107}, year = {1993} }