@article{oai:niigata-u.repo.nii.ac.jp:00020165,
 author = {中澤, 朝生},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {Vanadate of a trace element has been shown to have insulin-like effects. The effect of vanadate on some parameters of renal function was studied on streptozotocin-induced diabetic rats with heminephrectomy. Rats were divided into four groups as follows: vanadate (v)-untreated normal rats, v-treated normal rats, v-untreated diabetic rats and v-treated diabetic rats. Oral administration of vanadate was started three weeks after the induction of diabetes and continued for a period of 10 weeks. The v-treated diabetic rats were characterized by significant (p<0.001) decreases of blood glucose and of both albumin and IgG excretion rates after 8 weeks of study. There was no significant difference in the blood glucose and both albumin and IgG excretion rates between v-untreated normal rats and v-treated normal rats. The kidney wet weights of the v-untreated diabetic rats were significantly (p<0.01) greater than those in the v-treated diabetic rats. However there was no significant difference in the body weight and creatinine clearance between the v-treated diabetic rats and the v-untreated diabetic rats. The present findings suggest that glycemic control by oral administration of vanadate, which dose not cause insulin release, also improves diabetic renal function.},
 pages = {438--443},
 title = {糖尿病ラットにおけるバナデートの腎への効果},
 volume = {107},
 year = {1993}
}