@article{oai:niigata-u.repo.nii.ac.jp:00020163, author = {渡部, 久実 and 飯合, 恒夫 and 安保, 徹}, issue = {5}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {May}, note = {Extrathymic T cells in mouse liver have TCR of intermediate intensity, contain doublenegative CD4^-CD8^- cells, and comprise forbidden self-reactive oligoclones. In the present study, we investigated how such extrathymic T cells were modulated during melanoma development in melanoma transgenic mice. Melanoma appeared in various organ of the transgenic mice at 15 wk of age. Extrathymic T cells with TCR of intermediate intensity increased in the liver, as the tumors advanced. Such cells infiltated the tumor lesions. In consequence of this study, it was proved that extrathymic T cells in the liver played important roles in tumor immunity.}, pages = {425--429}, title = {7) メラノーマと胸腺外分化T細胞(シンポジウム 悪性黒色腫の現況と治療, 第477回新潟医学会)}, volume = {107}, year = {1993} }