@article{oai:niigata-u.repo.nii.ac.jp:00020121,
 author = {太田, 英男},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {In the isolated perfused rat heart, low-flow perfusion (0.5ml/min) resulted in a marked reduction of the left ventricular developed pressure. Ventricular arrhythmia developed and the ventricular endsiastolic pressure rose 10 min after initiation of low-flow perfusion. In the vehicletreated hearts the total arrhythmic period during 20 min of low-flow perfusion was 436±36 sec. The period was shorter in the presence of lidocaine, diltiazem and propranolol and the rise of EDP was attenuated. E-4031, a blocker of the delayed rectifier K channel, produced a shortening of the arrhythmic period and an attenuation of the rise of EDP only at a high concentration (100μM). In contrast, glibenclamide, a blocker of ATP-sensitive K channel, and bretylium, a quaternary ammonlum salt, reduced arrhthmic period without producing attenuation of the rise of EDP. These effects were inhibited by cromakalim, an ATP-sensitive K channel opener. Thus, the antiarrhythmic effects of diltiazem, propranolol, lidocaine and E-4031 were due to antiischemic action, while those of glibenclamide and bretylium were probably attributable to blockade of ATP-sensitive K channel.},
 pages = {512--522},
 title = {ラット摘出心における低灌流時不整脈に対する各種抗不整脈薬の効果},
 volume = {107},
 year = {1993}
}