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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第107巻第6号

ラット摘出心における低灌流時不整脈に対する各種抗不整脈薬の効果

http://hdl.handle.net/10191/37452
http://hdl.handle.net/10191/37452
63f69499-2edc-471f-90a1-c337eef8ae22
名前 / ファイル ライセンス アクション
107(6)_512-522.pdf 107(6)_512-522.pdf (1.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-02-03
タイトル
タイトル ラット摘出心における低灌流時不整脈に対する各種抗不整脈薬の効果
タイトル
言語 en
タイトル ラット摘出心における低灌流時不整脈に対する各種抗不整脈薬の効果
言語
言語 jpn
キーワード
主題Scheme Other
主題 Ischemia
キーワード
主題Scheme Other
主題 Arrhythmia
キーワード
主題Scheme Other
主題 Langendorff
キーワード
主題Scheme Other
主題 Antiarrhythmic agent
キーワード
主題Scheme Other
主題 虚血
キーワード
主題Scheme Other
主題 不整脈
キーワード
主題Scheme Other
主題 摘出心臓灌流標本
キーワード
主題Scheme Other
主題 抗不整脈薬
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Effects of Antiarrhythmic Agents on Low-perfusion Induced Arrhythmia in Isolated Rat Heart
著者 太田, 英男

× 太田, 英男

WEKO 124471

太田, 英男

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著者別名
識別子 124472
識別子Scheme WEKO
姓名 Ohta, Hideo
抄録
内容記述タイプ Abstract
内容記述 In the isolated perfused rat heart, low-flow perfusion (0.5ml/min) resulted in a marked reduction of the left ventricular developed pressure. Ventricular arrhythmia developed and the ventricular endsiastolic pressure rose 10 min after initiation of low-flow perfusion. In the vehicletreated hearts the total arrhythmic period during 20 min of low-flow perfusion was 436±36 sec. The period was shorter in the presence of lidocaine, diltiazem and propranolol and the rise of EDP was attenuated. E-4031, a blocker of the delayed rectifier K channel, produced a shortening of the arrhythmic period and an attenuation of the rise of EDP only at a high concentration (100μM). In contrast, glibenclamide, a blocker of ATP-sensitive K channel, and bretylium, a quaternary ammonlum salt, reduced arrhthmic period without producing attenuation of the rise of EDP. These effects were inhibited by cromakalim, an ATP-sensitive K channel opener. Thus, the antiarrhythmic effects of diltiazem, propranolol, lidocaine and E-4031 were due to antiischemic action, while those of glibenclamide and bretylium were probably attributable to blockade of ATP-sensitive K channel.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 107, 号 6, p. 512-522, 発行日 1993-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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