@article{oai:niigata-u.repo.nii.ac.jp:00020120,
 author = {清水, 武昭 and 佐藤, 攻 and 土屋, 嘉昭 and 内田, 克之 and 高沢, 哲也},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {Nutrition was transported by portal vein into the liver. Insulin and other gastrointestinal hormone was also carried in the portal vein into the liver. Recently, it was tried that insulin was infused into the portal vein directory for the procedure of direct catheter insertion to the portal vein for the treatment of diabetes melitus patients with surgical operation. This method was imposed the catheter trouble in the long time insertion. Recently, we found the new intraportal infusion method of drugs. This new method which was very simple, safety and easy was the utilization of grater omentum with absorption faculty. The catheter using drug infusion was inserted into the abdomen and the tip of catheter was covered by the greater omentum under laparotomy. We examined the insulin intraportal administration effect to the 15 patients with hepatectomy using this new method. The insulin spredded in the greater omentum pocket was absorbed quickly into the portal vein. The insulin level of portal vein was showed over the twice in comperared with the peripheral blood. In using 20 U human regular insulin with one shot through this catheter, the peak levels of insulin in portal vein was ranged 512.1 to 1334.4μu/ml (mean 865.5±423.1μu/ml) and in peripheral blood was raged 127.9 to 297.2μu/ml (mean 223.2±86.6μu/ml). The peak time in both blood was same, about 15min. The blood glucose levels in all patients with hepatectomy under the control of this new insulin administration method (group 1) were suppressed under the 200mg/dl. The blood glucose level in other group patients with hepatectomy was not controlled (group 2). The effect of this intraportal insulin administration method was determined the arterial blood keton body ratio in hepatectomy. At preoperative period, keton body ratio were the same in both group but intra and postoperative period, keton body ratio of group 1 ranged more than 0.7 and group 2 ranged under the 0.7. Conclusion: 1. New intraportal insulin administration method was useful to the patients with hepatectomy. 2. This method was easy safety and simple. Therefore, it was considered that the possibility of this intraportal insulin administration method to utilize the therapy to diabetes mellitus patients remained futhermore.},
 pages = {507--511},
 title = {新しい門脈内薬剤投与法とその検討 : 主にインシュリン門脈内投与法について},
 volume = {107},
 year = {1993}
}