@article{oai:niigata-u.repo.nii.ac.jp:00020119,
 author = {小山, 晃 and 湯浅, 龍彦 and 成富, 博章 and 澤田, 徹},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {We have studied dynamics of cerebrospinal fluid (CSF) in 15 patients with multiple lacunar infarcts. The patients were subdivided into two groups with dementia (MMT<23; n=9), and without dementia (MMT>24; n=6). The white matter lesions detected by CT or MRI as PVL or as diffuse high intensity lesions respectively were found dominantly in patients with dementia. In 6 out of 9 demented patients, the white matter lesions were so severe and they may called as having Binswanger disease. A ventricular dilataion index in the demented group was greater than that in non-demented group. RI cisternography was done in all patients and rCBF was studied in 13 patients. The rCBF was reduced in patients of the demented group. The CSF dynamics was disturbed in 4 out of 9 demented patients; slow velocity of CSF circulation demonstrated by prolonged peak latency of RI activity, although non of them exhibited ventricular reflux. After dranage of CSF by lumbar puncture, 4 patients in the demented group showed improvement of dementia score and ADL. Disturbance of CSF dynamics is one of important factor in concern about the pathogenesis of Binswanger disease.},
 pages = {496--506},
 title = {6) 慢性期脳血管障害における白質病変の発生メカニズムに関する考察 : 特に髄液循環動態を中心として(シンポジウム 血管障害の発生メカニズムと予防, 第473回新潟医学会)},
 volume = {107},
 year = {1993}
}