@article{oai:niigata-u.repo.nii.ac.jp:00020115, author = {岡田, 正彦}, issue = {6}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Jun}, note = {In this paper, we discuss the recent theory of pathogenesis of atherosclerosis. Endothelial cells of the vascular wall play an important role for controlling vascular tone, preventing thrombus formation, exchanging substances between blood and tissues, and so on. The increased level of low density lipoprotein (LDL), especially modified LDL will cause migration of monocyte-macrophages into sub-endothelial area. Modified LDL is taken up by the macrophages, which become form cells. Smooth muscle cells contribute to this process as well. These events are thought to be main parts in the pathogenesis of atherosclerosis. Some kinds of modifications of LDL, i.e. , oxidative modification of LDL, are also essential part of it. Shear stress which is caused by blood flow can accelerate the process.}, pages = {479--482}, title = {1) 血管障害の発生メカニズムを推理する(シンポジウム 血管障害の発生メカニズムと予防, 第473回新潟医学会)}, volume = {107}, year = {1993} }