@article{oai:niigata-u.repo.nii.ac.jp:00020027,
 author = {内藤, 眞},
 issue = {7},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jul},
 note = {Macrophages are heterogenous populations existing in various tissues and organs, performing multifacetted functions in physiological and pathological conditions. In ontogeny, primitive/fetal macrophages first develop in yolk sac hematopoiesis without passing through the differentiation pathway of monocytic series. Monocytic cells are a minor cell population in the early fetal period, and increase in the late stage. Primitive/fetal macrophages proliferate and survive in loco. Tissue macrophages in adult animals also proliferate and maintain their population by self renewal. In monocytopenic mice induced by administration of bone-seeking isotope, strontium-89, tissue resident macrophages do not decrease. In macrophage colony stimulating factor （M-CSF）-deficient mice （op/op）, monocytes as well as tissue macrophages are deficient. However, M-CSF-independent tissue macrophages and Langerhans/dendritic cells are present in the defective condition of monocyte differentiation into macrophages. These findings demonstrate that differentiation pathways of tissue macrophages and nonlymphoid dendritic cells are different from that of monocytes. As an example of the specific functions of macrophages, tissue distribution, intracellular localization and expression of scavenger receptors were presented with special reference to the role of macrophages in endocytosis of chemically modified low density lipoprotein and atherogenesis.},
 pages = {559--564},
 title = {マクロファージの発生分化機構と動脈硬化発症機序における役割},
 volume = {107},
 year = {1993}
}