{"created":"2023-07-26T01:14:03.035200+00:00","id":2001083,"links":{},"metadata":{"_buckets":{"deposit":"9b61f2f3-a4ec-46b3-bf13-b360fab37e0c"},"_deposit":{"created_by":4,"id":"2001083","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2001083"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02001083","sets":["453:455","471:561:562"]},"author_link":[],"control_number":"2001083","item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"item_6_degree_grantor_49","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"新潟大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Niigata University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"One of the causes of bleeding in subdural hematoma is cortical artery rupture, which is difficult to detect at autopsy. Therefore, reports of autopsy cases with this condition are limited and hence, the pathogenesis of subdural hematoma remains unclear. Herein, for the detection and morphological analysis of cortical artery ruptures as the bleeding sources of subdural hematoma, we used the tissue-clearing CUBIC (clear, unobstructed, brain/body imaging cocktails and computational analysis) method with light-sheet fluorescence microscopy and reconstructed the two-dimensional and three-dimensional images. Using the CUBIC method, we could clearly visualize and detect cortical artery ruptures that were missed by conventional methods. Indeed, the CUBIC method enables three-dimensional morphological analysis of cortical arteries including the ruptured area, and the creation of cross-sectional two-dimensional images in any direction, which are similar to histopathological images. This highlights the effectiveness of the CUBIC method for subdural hematoma analysis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Diagnostics. 2022, 12(11), 2875.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"item_6_description_53","attribute_value_mlt":[{"subitem_description":"新大博(医)第1825号","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"dissertation_number","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第2268号"}]},"item_6_relation_14":{"attribute_name":"item_6_relation_14","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/diagnostics12112875","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by the authors.","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Funayama, Kazuhisa","creatorNameLang":"en"},{"creatorName":"舟山, 一寿","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-26"}],"displaytype":"detail","filename":"r4nmo1825.pdf","filesize":[{"value":"3.32MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2001083/files/r4nmo1825.pdf"},"version_id":"8cdf541c-ac13-4fcc-9479-31b0d5de9e31"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-26"}],"displaytype":"detail","filename":"r4nmo1825_a.pdf","filesize":[{"value":"191KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","objectType":"abstract","url":"https://niigata-u.repo.nii.ac.jp/record/2001083/files/r4nmo1825_a.pdf"},"version_id":"0a6d594b-2de2-47b3-be26-f71bb4cd7084"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"subdural hematoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cortical artery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"arterial rupture","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"3D imaging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CUBIC","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Detection and Morphological Analysis of Micro-Ruptured Cortical Arteries in Subdural Hematoma : Three-Dimensional Visualization Using the Tissue-Clearing Clear, Unobstructed, Brain/Body Imaging Cocktails and Computational Analysis Method","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Detection and Morphological Analysis of Micro-Ruptured Cortical Arteries in Subdural Hematoma : Three-Dimensional Visualization Using the Tissue-Clearing Clear, Unobstructed, Brain/Body Imaging Cocktails and Computational Analysis Method","subitem_title_language":"en"},{"subitem_title":"硬膜下血腫における皮質動脈微小破裂の検出と形態解析 : CUBIC法による組織透明化を用いた3次元画像化","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"4","path":["455","562"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-07-26"},"publish_date":"2023-07-26","publish_status":"0","recid":"2001083","relation_version_is_last":true,"title":["Detection and Morphological Analysis of Micro-Ruptured Cortical Arteries in Subdural Hematoma : Three-Dimensional Visualization Using the Tissue-Clearing Clear, Unobstructed, Brain/Body Imaging Cocktails and Computational Analysis Method"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-10-03T06:02:44.281234+00:00"}