{"created":"2023-04-27T02:14:37.889706+00:00","id":2000970,"links":{},"metadata":{"_buckets":{"deposit":"ee33e2a3-8192-406a-9b4c-258031f61a7f"},"_deposit":{"id":"2000970","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000970"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000970","sets":["453:455","471:561:562"]},"author_link":[],"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-09-20"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"新潟大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Niigata University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Radiation therapy is one of the major treatment modalities for patients with cancers. However, ionizing radiation (IR) damages not only cancer cells but also the surrounding vascular endothelial cells (ECs). Hippo pathway effector genes Yap1 and Taz are the two transcriptional coactivators that have crucial roles in tissue homeostasis and vascular integrity in various organs. However, their function in adult ECs at the steady state and after IR is poorly understood. Here, we report sex- and context-dependent roles of endothelial YAP1/TAZ in maintaining vascular integrity and organismal survival. EC-specific Yap1/Taz deletion compromised systemic vascular integrity, resulting in lethal circulation failure preferentially in male mice. Furthermore, EC-specific Yap1/Taz deletion induced acute lethality upon sublethal IR that was closely associated with exacerbated systemic vascular dysfunction and circulation failure. Consistent with these findings, RNA-seq analysis revealed downregulation of tight junction genes in Yap1/Taz-deleted ECs. Collectively, our findings highlight the importance of endothelial YAP1/TAZ for maintaining adult vascular function, which may provide clinical implications for preventing organ injury after radiation therapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Biochemical and Biophysical Research Communications. 2022, 619, 117-123.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(医)第1091号","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第5078号"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbrc.2022.06.050","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 Elsevier Inc. All rights reserved.","subitem_rights_language":"en"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Uemura, Shun","creatorNameLang":"en"},{"creatorName":"上村, 駿","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-27"}],"displaytype":"detail","filename":"r4nmk1091.pdf","filesize":[{"value":"3.7MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000970/files/r4nmk1091.pdf"},"version_id":"94a1de42-b42c-410a-86f2-62b3d32bfc4f"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-27"}],"displaytype":"detail","filename":"r4nmk1091_a.pdf","filesize":[{"value":"438KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","objectType":"abstract","url":"https://niigata-u.repo.nii.ac.jp/record/2000970/files/r4nmk1091_a.pdf"},"version_id":"bfbd2818-833f-4b29-a753-3184cfa858cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Yes-associated protein 1 (YAP1)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"WW domain Containing transcription","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"regulator 1 (TAZ)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelial cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ionizing radiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lung","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tight junction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"YAP1/TAZ activity maintains vascular integrity and organismal survival","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"YAP1/TAZ activity maintains vascular integrity and organismal survival","subitem_title_language":"en"},{"subitem_title":"YAP1/TAZ活性は血管の恒常性と生体の生存に重要である","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-27"},"publish_date":"2023-04-27","publish_status":"0","recid":"2000970","relation_version_is_last":true,"title":["YAP1/TAZ activity maintains vascular integrity and organismal survival"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-04-27T02:14:43.323380+00:00"}