{"created":"2022-05-27T06:27:35.880396+00:00","id":2000534,"links":{},"metadata":{"_buckets":{"deposit":"6397bb89-f0b3-4ef2-8ce1-967b81a5f5b0"},"_deposit":{"id":"2000534","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000534"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000534","sets":["432:1291:1292:1653632400081","453:456"]},"author_link":[],"item_1627361970403":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"57","bibliographicPageStart":"51","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"新潟歯学会雑誌","bibliographic_titleLang":"ja"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In recent years, the elderly population has been growing, and subsequently, the number of patients complaining of xerostomia symptoms has been increasing. In this study, we focused on the moisturizing effects of trehalose. We developed a trehalose tablet as a novel supplement for xerostomia and compared it to a sucrose tablet for verification of its moisturizing effects. A total of 72 healthy female subjects were randomly assigned to receive either the sucrose or trehalose tablet, followed by the other. Subjects received a 14-question survey soon after each tablet had dissolved completely in the mouth. For objective evaluation of the tablets, compression and solubility tests were performed. Based on sensory (subjective) evaluation, the trehalose tablets provided significantly more moisturization in the mouth and a sense of salivation than the sucrose tablets. Therefore, trehalose may confer a greater effect on moisturizing the mouth than sucrose. In addition, the trehalose tablets were about 2/3 as soft and dissolved 2 to 3 times more quickly than the sucrose tablets. These subjective and objective evaluations suggest that trehalose is a better supplement for maintaining oral moisture than sucrose, and may therefore be useful as a therapeutic supplement. The use of this convenient and safe therapeutic supplement could help improve the quality of life of elderly individuals who are suffering from xerostomia by allowing them to better enjoy meals and conversation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"近年，高齢者の急激な増加に伴い，口腔乾燥症の症状を訴える患者も増加の一途を辿っている。本研究では，トレハロースの保湿効果に着目し，口腔乾燥のための新しい治療補助食品として，トレハロースタブレットを開発した。保湿効果の比較の為に蔗糖のタブレットも同時に開発し，効果について主観的，客観的に検証を行った。実験には72名の健常な女性に参加して頂き，タブレットを試食して口腔内で完全に溶解して消失してから，その後14項目のアンケート調査を実施した。また，タブレットの物性について客観的評価として，圧縮試験及び溶解度試験も合わせて実施した。主観的評価結果から，トレハロースが蔗糖と比較して，有意に口腔内の保湿に影響を与えている可能性が示された。また，客観的評価より，トレハロースタブレットは，蔗糖タブレットと比較して2/3程度軟らかく，口腔内で2～3倍早く溶解することが示された。これらの結果より，トレハロースタブレットは，口腔内の保湿に寄与することが示唆された。このことから，口腔内の乾燥で悩む高齢者に対しても効果が期待でき，食事や会話への楽しみ，QOLの向上へと繋げていく可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟歯学会","subitem_publisher_language":"ja"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0153","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川﨑, 真依子","creatorNameLang":"ja"},{"creatorName":"Kawasaki, Maiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"鈴木, 亜夕帆","creatorNameLang":"ja"},{"creatorName":"Suzuki, Ayuho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"坂井, 裕次","creatorNameLang":"ja"},{"creatorName":"Sakai, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"相田, 美和","creatorNameLang":"ja"},{"creatorName":"Sohda, Miwa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"五十嵐, 敦子","creatorNameLang":"ja"},{"creatorName":"Igarashi, Atsuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡邊, 智子","creatorNameLang":"ja"},{"creatorName":"Watanabe, Tomoko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-27"}],"displaytype":"detail","filename":"45(2)_51-57.pdf","filesize":[{"value":"426KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000534/files/45(2)_51-57.pdf"},"version_id":"e46541ac-7182-4d83-a90d-64dcaed96b74"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"トレハロース","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"保湿","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"加齢","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"trehalose","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"moisturization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"トレハロースタブレットの口腔保湿に対する効果の分析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"トレハロースタブレットの口腔保湿に対する効果の分析","subitem_title_language":"ja"},{"subitem_title":"Analysis of Oral Moisturizing Effects of Trehalose Tablets","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1653632400081"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-27"},"publish_date":"2022-05-27","publish_status":"0","recid":"2000534","relation_version_is_last":true,"title":["トレハロースタブレットの口腔保湿に対する効果の分析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:17:20.250746+00:00"}