{"created":"2022-05-26T06:33:48.721458+00:00","id":2000521,"links":{},"metadata":{"_buckets":{"deposit":"b8e3ae39-57ad-4427-b469-44b81e568af1"},"_deposit":{"id":"2000521","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000521"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000521","sets":["432:1291:1292:1653546419953","453:456"]},"author_link":[],"item_1627361970403":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"92","bibliographicPageStart":"83","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"新潟歯学会雑誌","bibliographic_titleLang":"ja"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tumor necrosis factor-alpha (TNF-α) has been suggested to regulate expression of enzymes that metabolize amino acids associated with rheumatoid arthritis (RA) and periodontitis. TNF-α inhibition has been reported to influence periodontal condition in patients with RA. The aim of the present study is to compare amino acid and periodontal profiles between RA patients with and without TNF targeted therapy. The study participants consisted of 52 RA patients whose informed consents were obtained with and without anti-TNF therapy (n=26 for RA-TNF group, and n=26 for RA-C group) and 29 healthy controls (H group). Clinical periodontal and rheumatologic parameter values and plasma levels of amino acids and immunoglobulin G to periodontopathic bacteria were evaluated. No differences were observed between the RA-TNF and RA-C groups in any parameter values, except for a significantly lower % sites with bleeding on probing (BOP) in the RA-TNF group (P<0.05). Of 21 amino acids, glutamic acid, tryptophan, and ornithine were significantly different in the concentrations between the RA-TNF and RA-C groups (P<0.05). A significantly negative correlation was found between tryptophan level and % of sites with BOP (P=0.03). No associations were obtained between other amino acid levels and periodontal conditions in patients with RA. These results suggest a difference in amino acid and periodontal profiles between RA patients with and without anti-TNF therapy.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"腫瘍壊死因子-alpha(TNF-α)はアミノ酸代謝酵素の発現を制御し，関節リウマチ(RA)と歯周炎に関与することが示唆されている。TNF-α阻害はRA患者の歯周状態に影響を及ぼすことが報告されている。本研究の目的は，RA患者のTNF標的療法の有無でアミノ酸・歯周プロファイルを比較することである。インフォームドコンセントが得られたRA患者52名のうち，TNF標的療法を受けたRA患者26名(RA-TNF阻害群)と受けてないRA患者26名(RA-対照群)，健常者29名を対象に，RA検査，歯周検査，血液採取を行った。血漿中のアミノ酸濃度と歯周病原細菌に対する免疫グロブリンG抗体価を測定した。RA-TNF阻害群ではRA-対照群と比べ，プロービング時の出血(BOP)陽性部位の割合が有意に低く(P<0.05)，それ以外の評価項目では有意差を認めなかった。TNF標的療法の有無で有意差が認められたのはglutamic acid, tryptophan, ornithine(P<0.05)で，tryptophanレベルとBOP陽性部位の割合との間に有意な負の相関が認められた(P=0.03)。以上の結果から，RA患者ではTNF標的療法の有無でアミノ酸および歯周プロファイルが異なることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟歯学会","subitem_publisher_language":"ja"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0153","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 哲夫","creatorNameLang":"ja"},{"creatorName":"Kobayashi, Tetsuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岡田, 萌","creatorNameLang":"ja"},{"creatorName":"Okada, Moe","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉江, 弘正","creatorNameLang":"ja"},{"creatorName":"Yoshie, Hiromasa","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-26"}],"displaytype":"detail","filename":"44(2)_83-92.pdf","filesize":[{"value":"586KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000521/files/44(2)_83-92.pdf"},"version_id":"4316de9a-66ba-44cd-b2c3-8d3c8893f987"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"関節リウマチ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アミノ酸","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍壊死因子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Rheumatoid arthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"periodontitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amino acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor necrosis factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"腫瘍壊死因子標的療法中の関節リウマチ患者におけるアミノ酸・歯周プロファイル","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍壊死因子標的療法中の関節リウマチ患者におけるアミノ酸・歯周プロファイル","subitem_title_language":"ja"},{"subitem_title":"Amino acid and periodontal profiles in rheumatoid arthritis patients with tumor necrosis factor targeted therapy","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1653546419953"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-26"},"publish_date":"2022-05-26","publish_status":"0","recid":"2000521","relation_version_is_last":true,"title":["腫瘍壊死因子標的療法中の関節リウマチ患者におけるアミノ酸・歯周プロファイル"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:17:12.296666+00:00"}