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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

シスプラチンとシラスタチンの併用治療は腎機能障害を抑制することでシスプラチン投与量を増やせ、抗腫瘍効果を増強させる

http://hdl.handle.net/10191/0002000466
fdab305b-0bcc-41cb-8c5f-12f90486ac06
名前 / ファイル ライセンス アクション
r3nmk1024.pdf 本文 (1.91MB)
r3nmk1024_a.pdf 要旨 (438KB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-05-10
タイトル
言語 en
タイトル Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity
タイトル
言語 ja
タイトル シスプラチンとシラスタチンの併用治療は腎機能障害を抑制することでシスプラチン投与量を増やせ、抗腫瘍効果を増強させる
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 有田, 将史

× 有田, 将史

en Arita, Masashi

ja 有田, 将史

Search repository
抄録
内容記述タイプ Abstract
内容記述 Cisplatin, one of the most active anticancer agents, is widely used in standard chemotherapy for various cancers. Cisplatin is more poorly tolerated than other chemotherapeutic drugs, and the main dose-limiting toxicity of cisplatin is its nephrotoxicity, which is dose-dependent. Although less toxic methods of cisplatin administration have been established, cisplatin-induced nephrotoxicity remains an unsolved problem. Megalin is an endocytic receptor expressed at the apical membrane of proximal tubules. We previously demonstrated that nephrotoxic drugs, including cisplatin, are reabsorbed through megalin and cause proximal tubular cell injury. We further found that cilastatin blocked the binding of cisplatin to megalin in vitro. In this study, we investigated whether cilastatin could reduce cisplatin-induced nephrotoxicity without influencing the antitumor effects of cisplatin. Nephrotoxicity was decreased or absent in mice treated with cisplatin and cilastatin, as determined by kidney injury molecule-1 staining and the blood urea nitrogen content. Combined with cilastatin, a twofold dose of cisplatin was used to successfully treat the mice, which enhanced the antitumor effects of cisplatin but reduced its nephrotoxicity. These findings suggest that we can increase the dose of cisplatin when combined with cilastatin and improve the outcome of cancer patients.
言語 en
内容記述
内容記述タイプ Other
内容記述 Scientific reports. 2021, 11(1), 750.
言語 en
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-020-80853-6
権利
言語 en
権利情報 【○!C】 The Author(s) 2021
権利
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 Creative Commons Attribution 4.0 International
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13101
学位授与機関名
言語 ja
学位授与機関名 新潟大学
学位授与機関名
言語 en
学位授与機関名 Niigata University
学位授与年月日
学位授与年月日 2021-09-21
学位授与番号
学位授与番号 甲第4934号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)第1024号
言語 ja
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