{"created":"2022-05-10T05:52:47.084841+00:00","id":2000463,"links":{},"metadata":{"_buckets":{"deposit":"866a4d2a-c689-4fb5-9732-4ddffb21ec3b"},"_deposit":{"id":"2000463","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000463"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000463","sets":["453:455","471:561:562"]},"author_link":[],"control_number":"2000463","item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-21"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"新潟大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Niigata University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dopaminergic neurotransmission is considered to play an important role not only in reward-based learning, but also in aversive learning. Here, we investigated the role of dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) in aversive memory formation in a passive avoidance test using D1R knockdown (KD) mice, in which the expression of D1Rs can conditionally and reversibly be controlled by doxycycline (Dox) treatment. We also performed whole-brain imaging after aversive footshock stimulation in activity-regulated cytoskeleton protein (Arc)-dVenus D1RKD mice, which were crossbred from Arc-dVenus transgenic mice and D1RKD mice, to examine the distribution of Arc-controlled dVenus expression in the hippocampus and cerebral cortex during aversive memory formation. Knockdown of D1R expression following Dox treatment resulted in impaired performance in the passive avoidance test and was associated with a decrease in dVenus expression in the cerebral cortex (visual, somatosensory, and motor cortices), but not the hippocampus, compared with control mice without Dox treatment. These findings indicate that D1R-mediated dopaminergic transmission is critical for aversive memory formation, specifically by influencing Arc expression in the cerebral cortex.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Neuroscience research. 2020, 156, 58-65.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(医)第1021号","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第4931号"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.neures.2020.04.006","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"【○!C】 2020 Published by Elsevier B.V.","subitem_rights_language":"en"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saito, Nae","creatorNameLang":"en"},{"creatorName":"齊藤, 奈英","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"date":[{"dateType":"Available","dateValue":"2022-05-10"}],"displaytype":"detail","filename":"r3nmk1021.pdf","filesize":[{"value":"1.73MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000463/files/r3nmk1021.pdf"},"version_id":"bb7d35c0-5cad-4a3c-9041-3f11be1bcceb"},{"date":[{"dateType":"Available","dateValue":"2022-05-10"}],"displaytype":"detail","filename":"r3nmk1021_a.pdf","filesize":[{"value":"440KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","objectType":"abstract","url":"https://niigata-u.repo.nii.ac.jp/record/2000463/files/r3nmk1021_a.pdf"},"version_id":"7ae61fec-cd4a-447a-9358-d2904dc044d5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Dopamine D1 receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aversive memory","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Arc","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Arg3.1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Venus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Three-dimensional imaging","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex","subitem_title_language":"en"},{"subitem_title":"ドーパミンD1受容体を介した神経伝達は、嫌悪記憶形成と大脳皮質におけるArc活性化に必要である。","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-10"},"publish_date":"2022-05-10","publish_status":"0","recid":"2000463","relation_version_is_last":true,"title":["Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:16:48.036365+00:00"}