@phdthesis{oai:niigata-u.repo.nii.ac.jp:02000463,
 author = {Saito, Nae and 齊藤, 奈英},
 month = {2022-05-10, 2022-05-10},
 note = {Dopaminergic neurotransmission is considered to play an important role not only in reward-based learning, but also in aversive learning. Here, we investigated the role of dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) in aversive memory formation in a passive avoidance test using D1R knockdown (KD) mice, in which the expression of D1Rs can conditionally and reversibly be controlled by doxycycline (Dox) treatment. We also performed whole-brain imaging after aversive footshock stimulation in activity-regulated cytoskeleton protein (Arc)-dVenus D1RKD mice, which were crossbred from Arc-dVenus transgenic mice and D1RKD mice, to examine the distribution of Arc-controlled dVenus expression in the hippocampus and cerebral cortex during aversive memory formation. Knockdown of D1R expression following Dox treatment resulted in impaired performance in the passive avoidance test and was associated with a decrease in dVenus expression in the cerebral cortex (visual, somatosensory, and motor cortices), but not the hippocampus, compared with control mice without Dox treatment. These findings indicate that D1R-mediated dopaminergic transmission is critical for aversive memory formation, specifically by influencing Arc expression in the cerebral cortex., Neuroscience research. 2020, 156, 58-65., 新大院博(医)第1021号},
 school = {新潟大学, Niigata University},
 title = {Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex},
 year = {}
}