{"created":"2022-05-10T05:52:36.816857+00:00","id":2000460,"links":{},"metadata":{"_buckets":{"deposit":"b909ca5c-ffbf-41ee-b3f5-a86be86273a5"},"_deposit":{"id":"2000460","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000460"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000460","sets":["453:455","471:561:562"]},"author_link":[],"control_number":"2000460","item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-21"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"新潟大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Niigata University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative \"endometrium-related disease,\" and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"iScience. 2021, 24(4), 102258.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(医)第1018号","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第4928号"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.isci.2021.102258","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"【○!C】 2021 The Author(s).","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamaguchi, Manako","creatorNameLang":"en"},{"creatorName":"山口, 真奈子","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"date":[{"dateType":"Available","dateValue":"2022-05-10"}],"displaytype":"detail","filename":"r3nmk1018.pdf","filesize":[{"value":"38.48MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000460/files/r3nmk1018.pdf"},"version_id":"98c0d706-4a32-451a-8f80-c7187c0702a7"},{"date":[{"dateType":"Available","dateValue":"2022-05-10"}],"displaytype":"detail","filename":"r3nmk1018_a.pdf","filesize":[{"value":"440KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","objectType":"abstract","url":"https://niigata-u.repo.nii.ac.jp/record/2000460/files/r3nmk1018_a.pdf"},"version_id":"7424f95f-4f07-430a-b50a-0ee0fc988586"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Three-dimensional understanding of the morphological complexity of the human uterine endometrium","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Three-dimensional understanding of the morphological complexity of the human uterine endometrium","subitem_title_language":"en"},{"subitem_title":"組織透明化技術によるヒト子宮内膜の立体構造の解明","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-10"},"publish_date":"2022-05-10","publish_status":"0","recid":"2000460","relation_version_is_last":true,"title":["Three-dimensional understanding of the morphological complexity of the human uterine endometrium"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:16:51.407283+00:00"}