{"created":"2022-05-09T04:34:34.576721+00:00","id":2000443,"links":{},"metadata":{"_buckets":{"deposit":"1fdfd704-d6a7-4ef2-a6bc-fb36e9957f25"},"_deposit":{"id":"2000443","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000443"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000443","sets":["432:433:434","453:455"]},"author_link":[],"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-21"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"新潟大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Niigata University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"After dental implantation, osteopontin (OPN) is deposited on the hydroxyapatite (HA) blasted implant surface followed by direct osteogenesis, which is significantly disturbed in Opn-knockout (KO) mice. However, whether applying OPN on the implant surface promotes direct osteogenesis remains unclarified. This study analyzed the effects of various OPN modified protein/peptides coating on the healing patterns of the bone-implant interface after immediately placed implantation in the maxilla of four-week-old Opn-KO and wild-type (WT) mice. The decalcified samples were processed for immunohistochemistry for OPN and Ki67 and TRAP histochemistry. In the WT mice, the proliferative activity in the HA binding peptide-OPN mimic peptide fusion coated group was significantly higher than that in the control group from day 3 to week 1, and OPN deposition on the implant surface significantly increased in the recombinant-mouse-OPN (rOPN) group compared to the RGDS group on week 2. The rOPN group achieved the same rates of direct osteogenesis and osseointegration as those in the control group in a half period (on week 2). None of the implant surfaces could rescue the direct osteogenesis in the healing process in the Opn-KO mice. These results suggest that the rOPN coated implant enhances direct osteogenesis during osseointegration following implantation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"International Journal of Molecular Sciences. 2022, 23(3), 1039.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(歯)第494号","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第4944号"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms23031039","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Makishi, Sanako","creatorNameLang":"en"},{"creatorName":"真喜志, 佐奈子","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"date":[{"dateType":"Available","dateValue":"2022-05-09"}],"displaytype":"detail","filename":"r3ndk494.pdf","filesize":[{"value":"11.2MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000443/files/r3ndk494.pdf"},"version_id":"28052143-bda2-4298-ac1d-ed7163bb0471"},{"date":[{"dateType":"Available","dateValue":"2022-05-09"}],"displaytype":"detail","filename":"r3ndk494_a.pdf","filesize":[{"value":"237KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","objectType":"abstract","url":"https://niigata-u.repo.nii.ac.jp/record/2000443/files/r3ndk494_a.pdf"},"version_id":"8352b322-db3f-4a4c-b2c2-42c8f11a6d54"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Osteopontin on the dental implant surface promotes direct osteogenesis in osseointegration","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Osteopontin on the dental implant surface promotes direct osteogenesis in osseointegration","subitem_title_language":"en"},{"subitem_title":"デンタルインプラント表面のオステオポンチンはオッセオインテグレーションにおける直接性骨形成を促進する","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["455","434"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-09"},"publish_date":"2022-05-09","publish_status":"0","recid":"2000443","relation_version_is_last":true,"title":["Osteopontin on the dental implant surface promotes direct osteogenesis in osseointegration"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:35:52.701617+00:00"}