{"_buckets": {"deposit": "32fd45f6-1d69-48b2-ba83-c5a8b4093260"}, "_deposit": {"id": "2000367", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000367"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:02000367", "sets": ["455", "434"]}, "author_link": [], "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2021-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "新潟大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "Niigata University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13101", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（歯学）", "subitem_degreename_language": "ja"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: Food-derived peptides have been reported to exhibit antibacterial activity against periodontal pathogenic bacteria. However, no effect has been shown on inflammation and bone resorption in periodontal pathology. The overall objective of the current study was to investigate how rice peptides influence biological defense mechanisms against periodontitis-induced inflammatory bone loss, and identify their novel functions as a potential anti-inflammatory drug. Design: The expression of inflammatory and osteoclast-related molecules was examined in mouse macrophagederived RAW 264.7 cell cultures using qPCR. Subsequently, the effect of these peptides on inflammatory bone loss in mouse periodontitis was examined using a mouse model of tooth ligation. Briefly, periodontal bone loss was induced for 7 days in mice by ligating the maxillary second molar and leaving the contralateral tooth unligated (baseline control). The mice were microinjected daily with the peptide in the gingiva until the day before euthanization. One week after the ligation, TRAP-positive multinucleated cells (MNCs) were enumerated from five random coronal sections of the ligated sites in each mouse. Results: Rice peptides REP9 and REP11 significantly inhibited transcription activity of inflammatory and osteoclast-related molecules. Local treatment with the rice peptides, in mice subjected to ligature-induced periodontitis, inhibited inflammatory bone loss, explaining the decreased numbers of osteoclasts in bone tissue sections. Conclusion: Therefore, these data suggested that the rice peptides possess a protective effect against periodontitis.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Archives of Oral Biology. 2019, 98, 132-139.", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(歯)第479号", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第4871号"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.archoralbio.2018.11.021", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "【○!C】 2018 Elsevier Ltd. All rights reserved.", "subitem_rights_language": "en"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tamura, Hikaru", "creatorNameLang": "en"}, {"creatorName": "田村, 光", "creatorNameLang": "ja"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"date": [{"dateType": "Available", "dateValue": "2022-04-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r2ndk479.pdf", "filesize": [{"value": "1.49MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "1.49MB", "url": {"label": "本文", "objectType": "fulltext", "url": "https://niigata-u.repo.nii.ac.jp/record/2000367/files/r2ndk479.pdf"}, "version_id": "cff3b19b-65a8-4d6f-952d-d73e6cb82fd7"}, {"date": [{"dateType": "Available", "dateValue": "2022-04-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r2ndk479_a.pdf", "filesize": [{"value": "263KB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "263KB", "url": {"label": "要旨", "objectType": "abstract", "url": "https://niigata-u.repo.nii.ac.jp/record/2000367/files/r2ndk479_a.pdf"}, "version_id": "f1742092-b6af-41c9-9920-0f3cfc0acf5f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Food peptide", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Periodontitis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Inflammation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bone loss", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Osteoclastogenesis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis", "subitem_title_language": "en"}, {"subitem_title": "コメ胚乳タンパク質由来ペプチドは，歯周炎モデルマウスにおける歯槽骨吸収を抑制する", "subitem_title_language": "ja"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "434"], "permalink_uri": "http://hdl.handle.net/10191/0002000367", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-04-15"}, "publish_date": "2022-04-15", "publish_status": "0", "recid": "2000367", "relation": {}, "relation_version_is_last": true, "title": ["Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis"], "weko_shared_id": -1}