{"created":"2022-04-15T06:23:40.338672+00:00","id":2000366,"links":{},"metadata":{"_buckets":{"deposit":"7dd9abf2-aa5c-4604-9ef4-7bf669a6e40b"},"_deposit":{"id":"2000366","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000366"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000366","sets":["432:433:434","453:455"]},"author_link":[],"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"新潟大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Niigata University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Previous studies have reported associations between nonalcoholic fatty liver disease, periodontitis, and obesity. Serum immunoglobulin G (IgG) antibody titer against Porphyromonas gingivalis, a major pathogen of periodontitis, is an established indicator of periodontal infection. However, the relationship between the antibody titer and liver enzyme levels has not been clarified yet. A study in the elderly was needed to evaluate the effect of long-term persistent bacterial infection on liver function. The objective of this study was to investigate the association between liver function and infection by P. gingivalis, and the effect of obesity on the association. Methods: A cross-sectional study was conducted in adult outpatients visiting Sado General Hospital, in Niigata Prefecture, Japan, from 2008 to 2010. The final participants included 192 men and 196 women (mean age 68.1 years). Multivariable logistic regression analyses were performed to assess the association between the serum IgG antibody titer and the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamine transferase (GGT) levels. Results: In women, serum IgG antibody titers against P. gingivalis was associated with elevated ALT, but not with AST or GGT, independent of covariates (p = 0.015). No significant association was found between the antibody titer and the elevated liver enzymes in men. The effect of obesity on the relationship between antibody titer and liver enzyme levels was not statistically significant. Conclusions: A cross-sectional analysis of adult outpatients suggested an association between P. gingivalis infection and ALT levels in women. The effect of obesity on this association was not statistically significant.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Heliyon, 2020, 6(11), e05531.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(歯)第478号","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第4870号"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.heliyon.2020.e05531","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"【○!C】 2020 The Authors. Published by Elsevier Ltd. ","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takamisawa, Kei","creatorNameLang":"en"},{"creatorName":"髙見澤, 圭","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"date":[{"dateType":"Available","dateValue":"2022-04-15"}],"displaytype":"detail","filename":"r2ndk478.pdf","filesize":[{"value":"713KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000366/files/r2ndk478.pdf"},"version_id":"be0cf93a-653c-4aae-b425-b391b92c171b"},{"date":[{"dateType":"Available","dateValue":"2022-04-15"}],"displaytype":"detail","filename":"r2ndk478_a.pdf","filesize":[{"value":"237KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","objectType":"abstract","url":"https://niigata-u.repo.nii.ac.jp/record/2000366/files/r2ndk478_a.pdf"},"version_id":"c2a45594-3fef-4b5f-9401-ee533cbf240e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Clinical research","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dentistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatobiliary system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Internal medicine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver enzymes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Periodontitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Obesity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Porphyromonas gingivalis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Association between serum IgG antibody titers against Porphyromonas gingivalis and liver enzyme levels : A cross-sectional study in Sado Island","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between serum IgG antibody titers against Porphyromonas gingivalis and liver enzyme levels : A cross-sectional study in Sado Island","subitem_title_language":"en"},{"subitem_title":"血清抗Porphyromonas gingivalis IgG抗体価と血清肝機能マーカー値との関連性 : 新潟県佐渡市における横断研究","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["455","434"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-15"},"publish_date":"2022-04-15","publish_status":"0","recid":"2000366","relation_version_is_last":true,"title":["Association between serum IgG antibody titers against Porphyromonas gingivalis and liver enzyme levels : A cross-sectional study in Sado Island"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:13:41.180488+00:00"}