@phdthesis{oai:niigata-u.repo.nii.ac.jp:02000299, author = {Nakano, Hideyuki and 中野, 英之}, month = {2022-04-04, 2022-04-04}, note = {We aimed to evaluate choroid structural changes using swept-source optical coherence tomography (SS-OCT) following hemodialysis initiation in diabetic and nondiabetic patients with end-stage kidney disease (ESKD). In this multicenter, prospective, cross-sectional study, diabetic (DM group; 30 eyes; 16 patients) and nondiabetic patients (NDM group; 30 eyes; 15 patients) with ESKD were evaluated after hemodialysis initiation. SS-OCT findings were analyzed using a manual delineation technique and binarization method before the first and last hemodialysis sessions, conducted approximately 2 weeks apart. Subfoveal choroidal thickness changes and mean large choroidal vessel layer thickness were significantly greater in the DM group (−13.3%±2.5% and −14.5%±5.2%, respectively) than the NDM group (−9.5%±3.1% and −9.2%±3.4%, respectively; p = 0.049 and p = 0.02, respectively). Binarized SS-OCT analysis revealed that the mean subfoveal choroidal area was significantly larger in the DM group (−21.9%±6.5%) than the NDM group (−17.2%±5.9%; p = 0.032). The change ratio in mean luminal area values was significantly greater in the DM group (−27.7%±8.7%) than the NDM group (−17.7%±5.8%; p = 0.007). The DM group exhibited substantial changes in the choroidal layer, possibly reflecting choroidal vascular disorders caused by diabetes., PLoS ONE. 2020, 15(9), e0239072., 新大院博(医)第994号}, school = {新潟大学, Niigata University}, title = {Choroid structure analysis following initiation of hemodialysis using swept-source optical coherence tomography in patients with and without diabetes}, year = {} }