{"created":"2022-04-04T06:58:41.951774+00:00","id":2000287,"links":{},"metadata":{"_buckets":{"deposit":"6e1fb266-da29-4eec-8a07-217c56e8b78a"},"_deposit":{"id":"2000287","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000287"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000287","sets":["453:455","471:561:562"]},"author_link":[],"control_number":"2000287","item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"新潟大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Niigata University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"筋萎縮性側索硬化症(amyotrophic lateral sclerosis: ALS)は，上位運動ニューロン(upper motor neuron: UMN)および下位運動ニューロン(lower motor neuron: LMN)が侵される神経変性疾患である．病理学的には，運動神経細胞やグリア細胞に，TAR DNA-binding protein 43kDa(TDP-43)陽性の凝集体が認められる．このことから，病態として，異常TDP-43が，局所から伝播し広がっていくとする仮説が提唱されている．本研究では，この仮説を検証するため，特定の脳領域あるいは細胞種にTDP-43陽性凝集体を形成するマウスモデルの開発を目的とした．まず凝集体を作りやすい変異TDP-43を発現するアデノ随伴ウイルスを作製した．これを大脳皮質，脊髄，あるいは骨格筋に発現させ，特定の細胞種や領域に，TDP-43陽性凝集体を高効率に作成し得た．本研究で確立したマウスモデルは，TDP-43陽性凝集体の伝播を明らかとするのに貢献すると期待される．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(医)第982号","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第4828号"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坪口, 晋太朗","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"date":[{"dateType":"Available","dateValue":"2022-04-04"}],"displaytype":"detail","filename":"r2nmk982.pdf","filesize":[{"value":"4.80MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000287/files/r2nmk982.pdf"},"version_id":"815ea13b-347f-42da-ab08-e0018c076ba5"},{"date":[{"dateType":"Available","dateValue":"2022-04-04"}],"displaytype":"detail","filename":"r2nmk982_a.pdf","filesize":[{"value":"545KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","objectType":"abstract","url":"https://niigata-u.repo.nii.ac.jp/record/2000287/files/r2nmk982_a.pdf"},"version_id":"a1280272-eb04-43bf-b2bc-d24a45150039"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"筋萎縮性側索硬化症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"TDP-43陽性凝集体","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"伝播","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"アデノ随伴ウイルス","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"マウスモデル","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-04"},"publish_date":"2022-04-04","publish_status":"0","recid":"2000287","relation_version_is_last":true,"title":["TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:29:02.367063+00:00"}