@article{oai:niigata-u.repo.nii.ac.jp:00019947,
 author = {重野, 直也},
 issue = {8},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Aug},
 note = {Methicillin （DMPPC）-resistant Staphylococcus aureus （MRSA） is charactecteristic of resistance agaist not only DMPPC but other multiple antibiotics. The pattern of drug resistance is variable among MRSA strains, but DMPPC resistance is common. 1）DMPPC resistance of MRSA MRSA produces a specific enzyme named penicillin-binding protein 2'（PBP2'） which is not able to be detected from sensitive S.aureus. The protein production is inducible by β-lactam antibiotics. The property of the enzyme production is very stable because it is coded on a chromosomal gene, mecA. The resistance is temperature-sensitive and lost in acid condition. 2）Multiple drug resistance of MRSA Most of MRSA strains are β-lactamase-positive. In addition to β-lactam resistance, MRSA shows resistance to tetracylines and aminogycoside antibiotics with various levels and frequencies. The drug resistance depends on plasimids.},
 pages = {672--674},
 title = {1）-①MRSAの耐性機構 : 綜説(シンポジウム MRSA感染, 現状と対策, 第480回新潟医学会)},
 volume = {107},
 year = {1993}
}