@article{oai:niigata-u.repo.nii.ac.jp:00001993,
 author = {Ohta, Takeshi and Miyajima, Katsuhiro and Yamada, Takahisa},
 issue = {22},
 journal = {Journal of animal and veterinary advances, Journal of animal and veterinary advances},
 month = {Dec},
 note = {A high-sucrose diet induces insulin resistance and dyslipidemia in normal rats. The purpose of the present study was to investigate the effects of a high-sucrose diet on glycolipid metabolism in Spontaneously Diabetic Torii (SDT) rats, a genetic model of nonobese type 2 diabetes. Male SDT rats were fed with a high-sucrose (68% of energy) diet from 8-24 weeks of age. SDT rats fed a high-sucrose diet showed hypercholesterolemia, hyperinsulinemia and hyperleptinemia but the body weight and the serum triglyceride level were not increased. Unexpectedly in SDT rats fed a high-sucrose diet, we observed a suppress of the incidence of diabetes mellitus. In computed tomography analysis, SDT rats fed a high-sucrose diet showed an increase of visceral or subcutaneous fat tissue weight. In pathological analyses, slight or mild fatty liver was observed by high-sucrose feeding. A high-sucrose diet in SDT rats induced dyslipidemia, insulin resistance and fat storage but not development of diabetes. High sucrose-fed diabetic rats are considered to be useful for further elucidation of complex mechanisms in glycolipid metabolic abnormality.},
 pages = {2883--2889},
 title = {Changes in Glycolipid Metabolism During A High-Sucrose Feeding in Spontaneously Diabetic Torii (SDT) Rats, A Genetic Model of Nonobese Type 2 Diabetes},
 volume = {9},
 year = {2010}
}