{"created":"2021-03-01T06:05:40.548938+00:00","id":1988,"links":{},"metadata":{"_buckets":{"deposit":"8108c81b-7679-4db9-b867-27af2ef4ee18"},"_deposit":{"id":"1988","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1988"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00001988","sets":["453:454","479:480:481"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"1000170-5","bibliographicPageStart":"1000170-1","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Journal Addiction Research & Therapy"},{"bibliographic_title":"Journal Addiction Research & Therapy","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inflammatory cytokines are implicated in the neurodevelopmental hypothesis for schizophrenia. Based on this hypothesis, we studied the establishment of rodent models for schizophrenia by subcutaneously challenging rat or mouse neonates with various cytokines. Because of the physical and behavioral difference between animal species; however, it is difficult to fully evaluate the appropriateness of rodent models. To overcome this problem, we attempted to establish a non-human primate model of schizophrenia. We subcutaneously injected epidermal growth factor (EGF: 0.3 mg/kg/day) to 3 male neonatal cynomolgus monkeys for a total of 7 or 9 days from 14 days of age. During the following 4 or 5 years, no abnormal behaviors were observed in these monkeys treated with EGF; however, at the age of 6 years, 1 monkey exhibited abnormal behavioral traits: stereotypic movement, vocalization, alert motion, and self injury. It was noteworthy that the monkey often showed agitation and clapped its hands over its eyes and bit his hands in periods of illumination, although not under darkened conditions. The behavioral abnormalities except vocalization were ameliorated by 10-day oral treatment with risperidone at 0.10 mg/kg/day. Although this study needs to be replicated, this case report suggests the possibility that hyper EGF signals at the perinatal stage of non-human primates result in post-pubertal behavioral/cognitive deficits, which possibly imitate some pathological features of human schizophrenia.","subitem_description_type":"Abstract"}]},"item_5_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"JART an open access journal (OMICS group)"}]},"item_5_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.4172/2155-6105.1000170","subitem_relation_type_select":"DOI"}}]},"item_5_relation_31":{"attribute_name":"異版である","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.readcube.com/articles/10.4172%2F2155-6105.1000170","subitem_relation_type_select":"URI"}}]},"item_5_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright(C)2014 Sakai M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_5_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21556105","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakai, Miwako"}],"nameIdentifiers":[{"nameIdentifier":"6491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kashiwahara, Masafumi"}],"nameIdentifiers":[{"nameIdentifier":"6492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakita, Akiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"6493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nawa, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"6494","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-29"}],"displaytype":"detail","filename":"5_1_1000170.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5_1_1000170.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/1988/files/5_1_1000170.pdf"},"version_id":"664a12a4-c779-477c-aadb-201ba670e881"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Schizophrenia","subitem_subject_scheme":"Other"},{"subitem_subject":"EGF","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammatory cytokines","subitem_subject_scheme":"Other"},{"subitem_subject":"Cynomolgus monkey","subitem_subject_scheme":"Other"},{"subitem_subject":"ErbB","subitem_subject_scheme":"Other"},{"subitem_subject":"Hallucination","subitem_subject_scheme":"Other"},{"subitem_subject":"Risperidone","subitem_subject_scheme":"Other"},{"subitem_subject":"Postpuberty","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"An Attempt of Non-human Primate Modeling of Schizophrenia with Neonatal Challenges of Epidermal Growth Factor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"An Attempt of Non-human Primate Modeling of Schizophrenia with Neonatal Challenges of Epidermal Growth Factor"},{"subitem_title":"An Attempt of Non-human Primate Modeling of Schizophrenia with Neonatal Challenges of Epidermal Growth Factor","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["454","481"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-19"},"publish_date":"2015-01-19","publish_status":"0","recid":"1988","relation_version_is_last":true,"title":["An Attempt of Non-human Primate Modeling of Schizophrenia with Neonatal Challenges of Epidermal Growth Factor"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:34:49.282868+00:00"}