@article{oai:niigata-u.repo.nii.ac.jp:00019827, author = {鈴木, 裕}, issue = {10}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Oct}, note = {Does transneuronal degeneration occur in the neurons of the spinal intermediate zone following the degeneration of the anterior horn cells in man?To clarify this problem, we quantitatively examined the neurons in the cervibal intermediate zone of a 56-year-old patient who had suffered accidental amputation of the right upper arm 38 years prior to death. Recently, we reported that the cervical anterior horn cells of the patient were reduced in number not only on the amputation side but also on the spared side. The present study revealed that medium-sized neurons in the cervical intermediate zone, which are supposed to be internuncial neurons, were decreased in number on the spared side as well as on the amputation side, and were mildly decreased on the spared side compared with those on the amputation side. These findings indicate that retrograde transsynaptic degeneration occurs in the internuncial neurons following degeneration of the anterior horn cells caused by amputation. In addition, degeneration of the commissural neurons in the intermediate zone may induce degeneration of the neurons in the intermediate zone and the anterior horn cells on the spared side.}, pages = {918--928}, title = {ヒト脊髄におけるtransneuronal degeneration : 上腕切断後長期経過剖検例における頚髄灰白質中間帯の所見}, volume = {107}, year = {1993} }