@article{oai:niigata-u.repo.nii.ac.jp:00019822, author = {大越, 章吾}, issue = {10}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Oct}, note = {Precore sequence locates at the 5' portion of the core region of hepatitis B virus (HBV) genome and play a role in the secretion of hepatitis B e antigen (HBeAg). Point mutation in the precore sequence was found in the HBV genome obtained from fulminant hepatitis B and HBeAb positive patients. Such mutant HBV may disturb host immune system and cause severe HBV infection. Causative agent of non-A, non-B hepatitis virus was molecularly cloned and named hepatitis C virus (HCV). It was expressed in yeast and the antibody against this antigen (anti-C100-3) was detected in about 70% of patients with posttransfusion hepatitis. Genomic structure of HCV was presented.}, pages = {881--884}, title = {2)肝炎ウイルスの分子生物学最近の知見(シンポジウム ウイルス性肝炎の診断と治療, 第479回新潟医学会)}, volume = {107}, year = {1993} }