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Point mutation in the precore sequence was found in the HBV genome obtained from fulminant hepatitis B and HBeAb positive patients. Such mutant HBV may disturb host immune system and cause severe HBV infection. Causative agent of non-A, non-B hepatitis virus was molecularly cloned and named hepatitis C virus \uff08HCV\uff09. It was expressed in yeast and the antibody against this antigen \uff08anti-C100-3\uff09 was detected in about 70% of patients with posttransfusion hepatitis. 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