@article{oai:niigata-u.repo.nii.ac.jp:00019821,
 author = {小島, 秀男},
 issue = {10},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Oct},
 note = {Most popular causative agent of hepatic injury in Japan is hepatitis viruses. And hepatitis viruses have been classified to type A, type B and type non-A, non-B untill 1989. Recent successive cloning of HCV-RNA opened the way to correct serological diagnosis of type C hepatitis. Detection of IgM class anti-HA （IgM anti-HA） in one point acute phase serum confirms the diagnosis of type A hepatitis. Type B hepatitis could be diagnosed by detection of HBs antigen. But two modes （persistent and transient） are known in HBV infection, and HBs antigenemia could not differenciate these two modes. Detection of high titered anti-HBc means persistent infection, and detection of IgM class anti-HBc （IgM HBc） means recent infection of of HBV or exacerbation of chronic hepatitis. Type C hepatitis could be diagnosed by detection of anti-HCV, and positive anti-HCV also believed to concurrent HCV viremia. HDV is defective virus and needs helper function of HBV for its replication. So, HDV could infect simultaneously with HBV or overinfect to HBV carriers. Detection of anti-HDV leads to the diagnosis of type D hepatitis. Though very low incidence of HDV infection in Japan, possibility of HDV infection should be considered in case of severe acute hepatitis type B or atypical exacerbation of chronic type B hepatitis.},
 pages = {875--881},
 title = {1）ウイルス性肝炎の診断と治療 : 血清学的診断(シンポジウム ウイルス性肝炎の診断と治療, 第479回新潟医学会)},
 volume = {107},
 year = {1993}
}