{"_buckets": {"deposit": "eea733ff-82b6-42b2-b767-13ac81448073"}, "_deposit": {"id": "19749", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19749"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00019749", "sets": ["456", "1155"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Relaxation Mechanisms of Nitroglycerin"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1993-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "1022", "bibliographicPageStart": "1017", "bibliographicVolumeNumber": "107", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Since 1879, nitroglycerin is used as a remedy for angina pectoris. There is no doubt as to the effectiveness of nitroglycerin in the relief from the pain. The mechanism of anti-anginal effects of nitroglycerin is exclusively thought to be dependent on its vasodilatatory effects. The emerging consensus strongly favours the involvement of cyclic GMP as the mediator of vascular smooth muscle relaxation elicited by nitroglycerin. It is believed that accumulated cyclic GMP activates cyclic GMP-dependent protein kinase (G-kinase), G-kinase phosphorylates target proteins and then relaxation is occurred. Two main pathways are proposed as the relaxation mechanisms, 1) lowering intracellular free Ca^\u003c2+\u003e concentration and 2) reducing C^\u003c2+\u003e sensitivity to contractile proteins. Mechanism 1) will be mainly discussed. The vasodilatory effects of nitroglycerin shows a tissue (vein vs. artery) and a region (large vs. small artery) selectivity. The precise mechanism of the selectivity is not known so far. The region selectivity of nitroglycerin on the canine coronary artery may be based upon the difference of guanylate cyclase activity.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "122492", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nakazawa, Mikio"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "仲澤, 幹雄"}], "nameIdentifiers": [{"nameIdentifier": "122491", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "107(12)_1017-1022.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "107(12)_1017-1022.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/19749/files/107(12)_1017-1022.pdf"}, "version_id": "e4c4eaa3-e05a-4771-95f5-b8bf386a63ba"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "nitroglycerin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cyclic GMP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "G-kinase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "smooth muscle", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ca^\u003c2+\u003e pump", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ニトログリセリン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "サイクリック GMP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "G-キナーゼ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "血管平滑筋", "subitem_subject_scheme": "Other"}, {"subitem_subject": "カルシウムポンプ", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Nitroglycerinの血管平滑筋弛緩機序", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Nitroglycerinの血管平滑筋弛緩機序"}, {"subitem_title": "Nitroglycerinの血管平滑筋弛緩機序", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1155"], "permalink_uri": "http://hdl.handle.net/10191/37813", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-02-05"}, "publish_date": "2016-02-05", "publish_status": "0", "recid": "19749", "relation": {}, "relation_version_is_last": true, "title": ["Nitroglycerinの血管平滑筋弛緩機序"], "weko_shared_id": null}