{"created":"2021-03-01T06:24:20.654221+00:00","id":19483,"links":{},"metadata":{"_buckets":{"deposit":"3a219c94-1337-483b-ac44-a20807c614b9"},"_deposit":{"id":"19483","owners":[],"pid":{"revision_id":0,"type":"depid","value":"19483"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00019483","sets":["453:456","471:537:538:1152"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Anti-Ribosomal Autoantibodies in Patients with Systemic Lupus Erythematosus (Recent Progress in Autoimmune Diseases)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"199","bibliographicPageStart":"194","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined sera from 90 active patients with systemic lupus erythematosus (SLE) for the presence of anti-ribosomal protein antibodies by Western-blotting, and also tested these sera for reactivity with ribosomal RNA (rRNA) by RNase T1 protection assay. Anti-P, anti-S10 and anti-L12 protein antibodies were detected in 38 (42%), 28 (31%) and 2 (2%) patients' sera, respectively. The anti-RNA antibody specific for the GTPase domain of 28S rRNA (anti-28S) was present in 15 (17%) sera. Cutaneous manifestations were dominant in anti-P, anti-S10 as well as anti-28S positive patients. Among 38 anti-P positive patients 3 developed acute lupus psychosis, and another 5 showed depression during their course of disease. These observations suggest that anti-ribosomal antibodies provide a useful marker for this disease. All anti-28S positive sera also contained anti-P activitiy and two of them have anti-L12 as well. There is no difference of anti-S10 frequency between anti-P positive sera and negative ones. It is therefore likely that strong association of three anti-ribosomal antibodies to the P proteins, L12 and GTPase domain of 28S RNA is due to an immune response against the limited RNA-protein complex domain in the ribodsome.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"121147","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sato, Takehiro"}]},{"nameIdentifiers":[{"nameIdentifier":"121148","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Uchiumi, Toshio"}]},{"nameIdentifiers":[{"nameIdentifier":"6","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kominami, Ryo"}]},{"nameIdentifiers":[{"nameIdentifier":"121150","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Arakawa, Masaaki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 健比呂"}],"nameIdentifiers":[{"nameIdentifier":"121143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内海, 利男"}],"nameIdentifiers":[{"nameIdentifier":"121144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木南, 凌"}],"nameIdentifiers":[{"nameIdentifier":"6","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川, 正昭"}],"nameIdentifiers":[{"nameIdentifier":"121146","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"108(3)_194-199.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"108(3)_194-199.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/19483/files/108(3)_194-199.pdf"},"version_id":"5b1759cf-129d-4d6e-9b03-da5262eae4fe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SLE","subitem_subject_scheme":"Other"},{"subitem_subject":"antiribosomal antibodies","subitem_subject_scheme":"Other"},{"subitem_subject":"lupus psychosis","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA-protein complex","subitem_subject_scheme":"Other"},{"subitem_subject":"全身性エリテマトーデス","subitem_subject_scheme":"Other"},{"subitem_subject":"抗リボソーム抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"ループス精神病","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA 蛋白質複合体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"5) 全身性エリテマトーデス患者血清中のリボソーム構成成分に対する自己抗体の解析(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"5) 全身性エリテマトーデス患者血清中のリボソーム構成成分に対する自己抗体の解析(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会)"}]},"item_type_id":"7","owner":"1","path":["456","1152"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-08"},"publish_date":"2016-02-08","publish_status":"0","recid":"19483","relation_version_is_last":true,"title":["5) 全身性エリテマトーデス患者血清中のリボソーム構成成分に対する自己抗体の解析(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:09:33.151798+00:00"}