@article{oai:niigata-u.repo.nii.ac.jp:00019483,
 author = {佐藤, 健比呂 and 内海, 利男 and 木南, 凌 and 荒川, 正昭},
 issue = {3},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Mar},
 note = {We examined sera from 90 active patients with systemic lupus erythematosus (SLE) for the presence of anti-ribosomal protein antibodies by Western-blotting, and also tested these sera for reactivity with ribosomal RNA (rRNA) by RNase T1 protection assay. Anti-P, anti-S10 and anti-L12 protein antibodies were detected in 38 (42%), 28 (31%) and 2 (2%) patients' sera, respectively. The anti-RNA antibody specific for the GTPase domain of 28S rRNA (anti-28S) was present in 15 (17%) sera. Cutaneous manifestations were dominant in anti-P, anti-S10 as well as anti-28S positive patients. Among 38 anti-P positive patients 3 developed acute lupus psychosis, and another 5 showed depression during their course of disease. These observations suggest that anti-ribosomal antibodies provide a useful marker for this disease. All anti-28S positive sera also contained anti-P activitiy and two of them have anti-L12 as well. There is no difference of anti-S10 frequency between anti-P positive sera and negative ones. It is therefore likely that strong association of three anti-ribosomal antibodies to the P proteins, L12 and GTPase domain of 28S RNA is due to an immune response against the limited RNA-protein complex domain in the ribodsome.},
 pages = {194--199},
 title = {5) 全身性エリテマトーデス患者血清中のリボソーム構成成分に対する自己抗体の解析(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会)},
 volume = {108},
 year = {1994}
}