{"created":"2021-03-01T06:24:13.111994+00:00","id":19367,"links":{},"metadata":{"_buckets":{"deposit":"75aaf9b5-c785-4bdd-a476-4f5c91d9b22c"},"_deposit":{"id":"19367","owners":[],"pid":{"revision_id":0,"type":"depid","value":"19367"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00019367","sets":["453:456","471:537:538:1150"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"CD56 Positive T Cells in Human : Characterization and Localization"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"366","bibliographicPageStart":"358","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In a series of recent studies, extrathymic T cell differentiation in mice has been reported. These T cells may be more primitive than that of thymic origin. Since they carry self reactive forbidden clones, it could be benefical for elimenating their own atypical cells. They express IL-2Rβ similar to NK cells, containing CD4 or CD8 double negative cells. Their morphology is large granular lymphocyte (LGL). This study is to elucidate the possibility that CD56 positive T cells with a morphology of LGL are the counterpart of extrathymic T cells in human. CD56 positive T cells were abundant in the liver comparing in peripheral blood from same donor. The phenotype of T cells in the liver mononuclear cells (MNC), CD56 positive T cells had considerably higher proportion of TCR-γδ aquisition, and CD4, CD8 double negative population were also existed in one of the case who had high population of CD56 positive T cells. While CD56 positive cells were absent in the thymus. CD56 positive T cells were able to proliferate in serum-rich medium condition supplemented with IL-2. CD56 positive T cells were also harvested from bone marrow cells in a liquid culture without thymic environment. These results described above and similarities of the extrathymic T cells in mice, strongly indicate the possibility that CD56 positive T cells is a counterpart of extrathymic T cells in humans.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"120561","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hashimoto, Shigeo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"橋本, 誠雄"}],"nameIdentifiers":[{"nameIdentifier":"120560","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"108(5)_358-366.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"108(5)_358-366.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/19367/files/108(5)_358-366.pdf"},"version_id":"b3aebdf0-d60e-4350-976f-cf0cc2d98b1c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD56 positive T cells in human","subitem_subject_scheme":"Other"},{"subitem_subject":"extrathymic T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"CD56陽性T細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"胸腺外分化T細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CD56陽性T細胞の特徴","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CD56陽性T細胞の特徴"},{"subitem_title":"CD56陽性T細胞の特徴","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1150"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-10"},"publish_date":"2016-02-10","publish_status":"0","recid":"19367","relation_version_is_last":true,"title":["CD56陽性T細胞の特徴"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:50:18.491935+00:00"}