{"created":"2021-03-01T06:24:00.645509+00:00","id":19180,"links":{},"metadata":{"_buckets":{"deposit":"97f5946c-b6cc-413e-9b30-58d0d4c03f9f"},"_deposit":{"id":"19180","owners":[],"pid":{"revision_id":0,"type":"depid","value":"19180"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00019180","sets":["453:456","471:537:538:1147"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Cardiohemodynamic Effects of Lacidipine, a Novel Calcium Antagonist"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"608","bibliographicPageStart":"593","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have examined the effects of lacidipine, a new dihydropyridine calcium antagonist, on cardiohemodynamics in comparison with those of nifedipine. Experiments were performed in open- and close-chest dogs anesthetized with morphine-α-chloralose-urethane and nitrous oxide. Lacidipine and nifedipine were administered intravenously at 1～30μg/kg. In open-chest dogs, both lacidipine and nifedipine produced dose-dependent decreases in diastolic and mean blood pressures (DBP and MBP) and increases in heart rate (HR) and left ventricular max dP/dt (LV max dP/dt). The decrease in MBP produced by nifedipine was transient; the MBP recovered to a level almost equal to the predrug level in a few minutes. In contrast, the effects of lacidipine were more prolonged except at low dose levels. On the basis of half-life assessed at a dose causing a decrement of MBP of a similar magnitude the hypotensive effect of lacidipine was >9 times longer-lasting than that of nifedipine. Both nifedipine and lacidipine decreased systolic blood pressure (SBP), left ventricular pressure (LVP) and left ventricular end-diastolic pressure (LVEDP) and increased cardiac output (CO). Lacidipine and nifedipine decreased total peripheral resistance (TPR) dose-dependently. The decreases were 20～50% for lacidipine and 15～40 % for nifedipine. Coronary blood flow (Cor-F) was increased to 50～175 % of the control after lecidipine and coronary vascular resistance (Cor-R) was decreased to 25～75%, while the changes were 40～240% and 35～70% after nifedipine. Decreases and increases were dose-dependent with both drugs. The increases in Cor-F exceeded those expected from the increases in MVO_2 observed simultaneously. In close-chest dogs, both nifedipine and lacidipine increased carotid and femoral blood flow (Car-F and Fern-F) and dose-dependently decreased carotid and femoral vascular resistance (Car-R and Fem-R). Coincident with the fall in BP renal blood flow (Ren-F) was decreased. Renal vascular resistance (Ren-R) was slightly decreased at all doses except for the maximum dose, at which it increased. The changes observed in blood flow in these vascular beds were less than 50% at the maximum and those in vascular resistance were less than 35%. Changes in MBP and HR were similar to those observed in open-chest dogs. Duration of action of lacidipine was longer than that of nifedipine. Like nifedipine the action of lacidipine was selective towards coronary artery.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"119448","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hara, Katsutoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"119449","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ishibashi, Takaharu"}]},{"nameIdentifiers":[{"nameIdentifier":"119450","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hamaguchi, Masami"}]},{"nameIdentifiers":[{"nameIdentifier":"119451","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imai, Shoichi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原, 勝利"}],"nameIdentifiers":[{"nameIdentifier":"119444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石橋, 隆治"}],"nameIdentifiers":[{"nameIdentifier":"119445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"濱口, 政巳"}],"nameIdentifiers":[{"nameIdentifier":"119446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井, 昭一"}],"nameIdentifiers":[{"nameIdentifier":"119447","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"108(8)_593-608.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"108(8)_593-608.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/19180/files/108(8)_593-608.pdf"},"version_id":"5aa18969-3a59-4530-b764-1ec165054bde"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lacidipine","subitem_subject_scheme":"Other"},{"subitem_subject":"nifedipine","subitem_subject_scheme":"Other"},{"subitem_subject":"calcium antagonist","subitem_subject_scheme":"Other"},{"subitem_subject":"dog","subitem_subject_scheme":"Other"},{"subitem_subject":"カルシウム拮抗薬","subitem_subject_scheme":"Other"},{"subitem_subject":"心血行動態","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋酸素消費量","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用"},{"subitem_title":"新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1147"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-18"},"publish_date":"2016-02-18","publish_status":"0","recid":"19180","relation_version_is_last":true,"title":["新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:50:05.092320+00:00"}